T helper 17 (Th17) cells and interleukin-17 (IL-17) in cancer

被引：75

作者：

Chang, Seon Hee ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2019年 / 42卷 / 07期

关键词：

Th17; cells; IL-17; Oncogene; Inflammation; Immunotherapy; Cancer; INTESTINAL EPITHELIAL-CELLS; TUMOR-GROWTH; T(H)17 CELLS; REGULATORY NETWORK; CLINICAL-RELEVANCE; IFN-GAMMA; TGF-BETA; PROMOTE; RECEPTOR; INFLAMMATION;

D O I：

10.1007/s12272-019-01146-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Th17 cells are a specialized subset of CD4+ T cells that are essential in driving inflammation during autoimmune disease and infection through a signature cytokine IL-17. Th17 cells have been found in various human cancers. The function of these cells in cancers is highly context-dependent; both tumor-promoting and tumor-suppressing activity have been reported. IL-17 and IL-22, Th17-derived cytokines, influence the tumor microenvironment by directly promoting transformed cell properties and neighboring stromal cell activity. These cytokines are also involved in regulation of the immune system by modulating the activities of myeloid cells and T cells. These findings suggest that Th17 cells and their cytokines are a key mediator of cancer development, representing a potential target for cancer therapy. Herein, I review recent preclinical studies on the function of Th17 cells and IL-17 in cancer and discuss possible therapeutic approaches to harness Th17 cells for cancer immunotherapy.

引用

页码：549 / 559

页数：11

共 98 条

[1] Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade [J].

Akbay, Esra A. ;

Koyama, Shohei ;

Liu, Yan ;

Dries, Ruben ;

Bufe, Lauren E. ;

Silkes, Michael ;

Alath, M. D. Maksudul ;

Magee, Dillon M. ;

Jones, Robert ;

Jinushi, Masahisa ;

Kulkarni, Meghana ;

Carretero, Julian ;

Wang, Xiaoen ;

Warner-Hatten, Tiquella ;

Cavanaugh, Jillian D. ;

Osa, Akio ;

Kumanogoh, Atsushi ;

Freeman, Gordon J. ;

Awad, Mark M. ;

Christiani, David C. ;

Bueno, Raphael ;

Hammerman, Peter S. ;

Dranoff, Glenn ;

Wong, Kwok-Kin .

JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (08) :1268-1279

[2] Phenotypic and functional features of human Th17 cells [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Santarlasci, Veronica ;

Maggi, Laura ;

Liotta, Francesco ;

Mazzinghi, Benedetta ;

Parente, Eliana ;

Fili, Lucia ;

Ferri, Simona ;

Frosali, Francesca ;

Giudici, Francesco ;

Romagnani, Paola ;

Parronchi, Paola ;

Tonelli, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861

[3] Th17 cellsin cancer: the ultimate identity crisis [J].

Bailey, Stefanie R. ;

Nelson, Michelle H. ;

Himes, Richard A. ;

Li, Zihai ;

Mehrotra, Shikhar ;

Paulos, Chrystal M. .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[4] Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorγT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung [J].

Balabko, Ljubov ;

Andreev, Katerina ;

Burmann, Nadine ;

Schubert, Melanie ;

Mathews, Martina ;

Trufa, Denis I. ;

Reppert, Sarah ;

Rau, Tilmann ;

Schicht, Martin ;

Sirbu, Horia ;

Hartmann, Arndt ;

Finotto, Susetta .

SCIENTIFIC REPORTS, 2014, 4

[5] An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients [J].

Bassolas-Molina, Helena ;

Raymond, Ernest ;

Labadia, Mark ;

Wahle, Joseph ;

Ferrer-Picon, Elena ;

Panzenbeck, Mark ;

Zheng, Jie ;

Harcken, Christian ;

Hughes, Robert ;

Turner, Michael ;

Smith, Dustin ;

Calderdon-Gomez, Elisabeth ;

Esteller, Miriam ;

Carrasco, Anna ;

Esteve, Maria ;

Dotti, Isabella ;

Maria Corraliza, Ma ;

Carme Masamunt, Maria ;

Arajol, Claudia ;

Guardiola, Jordi ;

Ricart, Elena ;

Nabozny, Gerald ;

Salas, Azucena .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[6] Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer [J].

Blatner, Nichole R. ;

Mulcahy, Mary F. ;

Dennis, Kristen L. ;

Scholtens, Denise ;

Bentrem, David J. ;

Phillips, Joseph D. ;

Ham, Soo ;

Sandall, Barry P. ;

Khan, Mohammad W. ;

Mahvi, David M. ;

Halverson, Amy L. ;

Stryker, Steven J. ;

Boller, Anne-Marie ;

Singal, Ashima ;

Sneed, Rebekka K. ;

Sarraj, Bara ;

Ansari, Mohammed Javeed ;

Oft, Martin ;

Iwakura, Yoichiro ;

Zhou, Liang ;

Bonertz, Andreas ;

Beckhove, Philipp ;

Gounari, Fotini ;

Khazaie, Khashayarsha .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (164)

[7] Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma [J].

Bonertz, Andreas ;

Weitz, Juergen ;

Pietsch, Dong-Ho Kim ;

Rahbari, Nuh N. ;

Schlude, Christoph ;

Ge, Yingzi ;

Juenger, Simone ;

Vlodavsky, Israel ;

Khazaie, Khashayarsha ;

Jaeger, Dirk ;

Reissfelder, Christoph ;

Antolovic, Dalibor ;

Aigner, Maximilian ;

Koch, Moritz ;

Beckhove, Philipp .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (11) :3311-3321

[8] Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology [J].

Buonocore, Sofia ;

Ahern, Philip P. ;

Uhlig, Holm H. ;

Ivanov, Ivaylo I. ;

Littman, Dan R. ;

Maloy, Kevin J. ;

Powrie, Fiona .

NATURE, 2010, 464 (7293) :1371-1375

[9] Lung Cancer Subtypes Generate Unique Immune Responses [J].

Busch, Stephanie E. ;

Hanke, Mark L. ;

Kargl, Julia ;

Metz, Heather E. ;

MacPherson, David ;

Houghton, A. McGarry .

JOURNAL OF IMMUNOLOGY, 2016, 197 (11) :4493-4503

[10] Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression [J].

Calcinotto, Arianna ;

Brevi, Arianna ;

Chesi, Marta ;

Ferrarese, Roberto ;

Perez, Laura Garcia ;

Grioni, Matteo ;

Kumar, Shaji ;

Garbitt, Victoria M. ;

Sharik, Meaghen E. ;

Henderson, Kimberly J. ;

Tonon, Giovanni ;

Tomura, Michio ;

Miwa, Yoshihiro ;

Esplugues, Enric ;

Flavell, Richard A. ;

Huber, Samuel ;

Canducci, Filippo ;

Rajkumar, Vincent S. ;

Bergsagel, P. Leif ;

Bellone, Matteo .

NATURE COMMUNICATIONS, 2018, 9

← 1 2 3 4 5 6 7 8 9 10 →