The effect of quercetin on the prevention or treatment of COVID-19 and other respiratory tract infections in humans: A rapid review

被引：43

作者：

Aucoin, Monique ^{[1
]}

Cooley, Kieran ^{[1
,2
,3
]}

Saunders, Paul Richard ^{[1
]}

Cardozo, Valentina ^{[1
]}

Remy, Daniella ^{[1
]}

Cramer, Holger ^{[2
,4
]}

Abad, Carlos Neyre ^{[5
]}

Hannan, Nicole ^{[6
]}

机构：

[1] Canadian Coll Naturopath Med, Toronto, ON, Canada

[2] Univ Technol Sydney, Australian Res Ctr Complementary & Integrat Med, Sydney, NSW, Australia

[3] Pacific Coll Hlth Sci, San Diego, CA USA

[4] Univ Duisburg Essen, Fac Med, Dept Internal & Integrat Med, Kliniken Essen Mitte, Essen, Germany

[5] Univ Calif Los Angeles, Los Angeles, CA USA

[6] Griffith Univ, Sch Pharm & Pharmacol, Gold Coast, Qld, Australia

来源：

ADVANCES IN INTEGRATIVE MEDICINE | 2020年 / 7卷 / 04期

关键词：

Quercetin; Respiratory tract infection; COVID; COVID-19; Rapid review; ILLNESS;

D O I：

10.1016/j.aimed.2020.07.007

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Brief overview: There is currently insufficient evidence to recommend quercetin supplementation as a therapy for the treatment or prevention of COVID-19. Three human clinical trials with low risk of bias suggest that oral quercetin may have a beneficial effect on the incidence and duration of respiratory tract infections in certain populations; however, further research is needed. Verdict: Current evidence on the efficacy of quercetin supplementation in the treatment and prevention of COVID-19 is insufficient for its clinical recommendation at this time. Quercetin exhibits both immunomodulatory and antimicrobial effects in preclinical studies; however, only three human clinical trials, each with a low risk of bias rating, were identified in this rapid review. One study reported a decrease in incidence of upper respiratory tract infections following a competitive athletic event. A larger community clinical trial reported a benefit in older, athletic adults only. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：247 / 251

页数：5

共 4 条

[1] Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial
Heinz, Serena A.
Henson, Dru A.
Austin, Melanie D.
Jin, Fuxia
Nieman, David C.
[J]. PHARMACOLOGICAL RESEARCH, 2010, 62 (03) : 237 - 242
[2] Post-160-km Race Illness Rates and Decreases in Granulocyte Respiratory Burst and Salivary IgA Output are Not Countered by Quercetin Ingestion
Henson, D.
Nieman, D.
Davis, J. M.
Dumke, C.
Gross, S.
Murphy, A.
Carmichael, M.
Jenkins, D. P.
Quindry, J.
McAnulty, S.
McAnulty, L.
Utter, A.
Mayer, E.
[J]. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2008, 29 (10) : 856 - 863
[3] Quercetin reduces illness but not immune perturbations after intensive exercise
Nieman, David C.
Henson, Dru A.
Gross, Sarah J.
Jenkins, David P.
Davis, J. Mark
Murphy, E. Angela
Carmichael, Martin D.
Dumke, Charles L.
Utter, Alan C.
McAnulty, Steven R.
McAnulty, Lisa S.
Mayer, Eugene P.
[J]. MEDICINE & SCIENCE IN SPORTS & EXERCISE, 2007, 39 (09) : 1561 - 1569
[4] Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry
Wu, Wenjiao
Li, Richan
Li, Xianglian
He, Jian
Jiang, Shibo
Liu, Shuwen
Yang, Jie
[J]. VIRUSES-BASEL, 2016, 8 (01):

← 1 →