Sex differences in pediatric traumatic brain injury

被引：42

作者：

Arambula, Sheryl E. ^{[1
]}

Reinl, Erin L. ^{[1
]}

El Demerdash, Nagat ^{[2
]}

McCarthy, Margaret M. ^{[1
]}

Robertson, Courtney L. ^{[2
,3
]}

机构：

[1] Univ Maryland, Sch Med, Dept Pharmacol, Baltimore, MD 21201 USA

[2] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Charlotte R Bloomberg Childrens Room 6321, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Pediat, Baltimore, MD 21287 USA

来源：

EXPERIMENTAL NEUROLOGY | 2019年 / 317卷

关键词：

Sex; Gender; Neuroinflammation; Excitotoxicity; Cerebral metabolism; Mitochondria; PROTECTS CEREBRAL AUTOREGULATION; CONTROLLED CORTICAL IMPACT; MEDIAL PREFRONTAL CORTEX; CEREBROSPINAL-FLUID; QUINOLINIC ACID; HIPPOCAMPAL NECROSIS; GABA(A) RECEPTOR; UNITED-STATES; CELL-DEATH; MICROGLIAL ACTIVATION;

D O I：

10.1016/j.expneurol.2019.02.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of significant sex differences in both the response to and the recovery from pediatric traumatic brain injury (TBI). These sex differences are seen at all pediatric ages, including neonates/infants, pre-pubertal children, and adolescents. As importantly, the response to neuroprotective therapies or treatments can differ between male and females subjects. These sex differences can result from several biologic origins, and may manifest differently during the various phases of brain and body development. Recognizing and understanding these potential sex differences is crucial, and should be considered in both preclinical and clinical studies of pediatric TBI.

引用

页码：168 / 179

页数：12

共 171 条

[1] Magnetic Resonance Spectroscopy Predicts Outcomes for Children With Nonaccidental Trauma
Aaen, Gregory S.
Holshouser, Barbara A.
Sheridan, Clare
Colbert, Cherie
McKenney, Melinda
Kido, Daniel
Ashwal, Stephen
[J]. PEDIATRICS, 2010, 125 (02) : 295 - 303
[2] Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior
Amateau, SK
McCarthy, MM
[J]. NATURE NEUROSCIENCE, 2004, 7 (06) : 643 - 650
[3] Amateau SK, 2002, J NEUROSCI, V22, P8586
[4] The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS
Anderson, KJ
Mason, KL
McGraw, TS
Theophilopoulos, DT
Sapper, MS
Burchfield, DJ
[J]. DEVELOPMENTAL BRAIN RESEARCH, 1999, 118 (1-2): : 69 - 77
[5] Understanding predictors of functional recovery and outcome 30 months following early childhood head injury
Anderson, VA
Catroppa, C
Dudgeon, P
Morse, SA
Haritou, F
Rosenfeld, JV
[J]. NEUROPSYCHOLOGY, 2006, 20 (01) : 42 - 57
[6] [Anonymous], 2002, HORMONES BRAIN BEHAV, DOI DOI 10.1016/B978-012532104-4/50071-8
[7] K Channel Impairment Determines Sex and Age Differences in Epinephrine-mediated Outcomes after Brain Injury
Armstead, William M.
Riley, John
Vavilala, Monica S.
[J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2017, 95 (10) : 1917 - 1926
[8] RETRACTED: Sex and Age Differences in Epinephrine Mechanisms and Outcomes after Brain Injury (Retracted Article)
Armstead, William M.
Riley, John
Vavilala, Monica S.
[J]. JOURNAL OF NEUROTRAUMA, 2017, 34 (08) : 1666 - 1675
[9] RETRACTED: Norepinephrine Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis after Traumatic Brain Injury via Blockade of ERK MAPK and IL-6 in Juvenile Pigs (Retracted article. See vol. 39, pg. 893, 2022)
Armstead, William M.
Riley, John
Vavilala, Monica S.
[J]. JOURNAL OF NEUROTRAUMA, 2016, 33 (19) : 1761 - +
[10] RETRACTED: Preferential Protection of Cerebral Autoregulation and Reduction of Hippocampal Necrosis With Norepinephrine After Traumatic Brain Injury in Female Piglets* (Retracted Article)
Armstead, William M.
Riley, John
Vavilala, Monica S.
[J]. PEDIATRIC CRITICAL CARE MEDICINE, 2016, 17 (03) : e130 - e137

← 1 2 3 4 5 6 7 8 9 10 →