A porous scaffold from bone-like powder loaded in a collagen-chitosan matrix

被引：11

作者：

Cui, K ^{[1
]}

Zhu, Y ^{[1
]}

Wang, MH ^{[1
]}

Feng, QL ^{[1
]}

Cui, FZ ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2004年 / 19卷 / 01期

关键词：

scaffold; biocompatibility; osteoblasts; biomimetic preparation;

D O I：

10.1177/0883911504042121

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Porous scaffolds that mimic both the structure and composition of natural bone were prepared. Nano-hydroxyapatite particles were first synthesized through deposition of minerals on self-assembled collagen fibrils. The porous scaffolds were then fabricated by loading the self-assembled nanohydroxyapatite-collagen composite powder into a cross-linked collagen-chitosan matrix. Porosity, mechanical properties, and composition of the scaffolds were studied. Biocompatibility was demonstrated by comparing in vitro osteoblasts-cultures, MTT assays, and alkaline phosphatase activity between the synthesized scaffolds and the control sample.

引用

页码：17 / 31

页数：15

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