Heat-processed Panax ginseng and diabetic renal damage: active components and action mechanism

被引:70
作者
Kang, Ki Sung [1 ]
Ham, Jungyeob [1 ]
Kim, Young-Joo [1 ]
Park, Jeong Hill [2 ,3 ]
Cho, Eun-Ju [4 ,5 ]
Yamabe, Noriko [4 ,5 ]
机构
[1] Korea Inst Sci & Technol, Nat Med Ctr, Kangnung 210340, South Korea
[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea
[3] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[4] Pusan Natl Univ, Dept Food Sci & Nutr, Pusan 609735, South Korea
[5] Pusan Natl Univ, Kimchi Res Inst, Pusan 609735, South Korea
关键词
Panax ginseng; Heat-processing; 20(S)-Rg3; Advanced glycation endproducts; Free radical; RADICAL-SCAVENGING ACTIVITY; GLYCATION END-PRODUCTS; TRADITIONAL CHINESE MEDICINE; 20(S)-GINSENOSIDE RG(3); INSULIN-RESISTANCE; MAILLARD REACTION; OXIDATIVE STRESS; AMERICAN GINSENG; KIDNEY-DISEASE; RED GINSENG;
D O I
10.5142/jgr.2013.37.379
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Diabetic nephropathy is one of the serious complications in patients with either type 1 or 2 diabetes mellitus but current treatments remain unsatisfactory. Results of clinical research studies demonstrate that Panax ginseng can help adjust blood pressure and reduce blood sugar and may be advantageous in the treatment of tuberculosis and kidney damage in people with diabetes. The heat-processing method to strengthen the efficacy of P ginseng has been well-defined based on a long history of ethnopharmacological evidence. The protective effects of P ginseng on pathological conditions and renal damage associated with diabetic nephropathy in the animal models were markedly improved by heat-processing. The concentrations of less-polar ginsenosides (20(S)-Rg3, 20(R)-Rg3, Rg5, and Rk1) and maltol in P ginseng were significantly increased in a heat-processing temperature-dependent manner. Based on researches in animal models of diabetes, ginsenoside 20(S)-Rg3 and maltol were evaluated to have therapeutic potential against diabetic renal damage. These effects were achieved through the inhibition of inflammatory pathway activated by oxidative stress and advanced glycation endproducts. These findings indicate that ginsenoside 20(S)-Rg3 and maltol are important bioactive constituents of heat-processed ginseng in the control of pathological conditions associated with diabetic nephropathy.
引用
收藏
页码:379 / 388
页数:10
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