Isolation, characterization, and neuroprotective activities of sesquiterpenes from Petasites japonicas

被引：43

作者：

Wang, Shaonan ^{[1
,2
]}

Jin, Da-Qing ^{[3
]}

Xie, Chunfeng ^{[1
,2
]}

Wang, Hao ^{[1
,2
]}

Wang, Meicheng ^{[1
,2
]}

Xu, Jing ^{[1
,2
]}

Guo, Yuanqiang ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab Med Chem Biol, Coll Pharm, Tianjin 300071, Peoples R China

[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China

[3] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China

来源：

FOOD CHEMISTRY | 2013年 / 141卷 / 03期

关键词：

Petasites japonicus; Sesquiterpenes; Neuroprotective activities; Parkinson's disease; EXTRACT;

D O I：

10.1016/j.foodchem.2013.04.116

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Neuroprotective reagents to protect the nerve cells against oxidative stress and other damages are potentially effective for the medical treatment of Parkinson's disease. Petasites japonicas, a wild vegetable, belongs to the family Compositae and its extract has shown the neuroprotective effects. A further phytochemical investigation of P. japonicas for neuroprotective substances led to the isolation of eight new (18) and two known (9 and 10) sesquiterpenes. Their structures were elucidated on the basis of extensive 1-D and 2D NMR (HMQC, HMBC, H-1-H-1 COSY, and NOESY) spectroscopic data analyses, and the structure of 1 was confirmed by X-ray crystallography. The neuroprotective activities of these sesquiterpenes were evaluated against cobalt chloride (COCl2)-induced neuronal cell death in human dopaminergic SH-SY5Y cells. Five compounds showed a neuroprotective activity. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2075 / 2082

页数：8

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