The HHEX gene is not related to congenital heart disease in 296 Chinese patients

被引：2

作者：

Deng, Xiao-Peng ^{[1
]}

Zhao, Li-Xi ^{[2
,3
]}

Wang, Bin-Bin ^{[2
,3
]}

Wang, Jing ^{[2
,3
]}

Cheng, Long-Fei ^{[2
,3
]}

Cheng, Zhi ^{[2
,3
]}

Suo, Pei-Su ^{[2
,3
]}

Li, Hui ^{[1
]}

Ma, Xu ^{[2
,3
,4
]}

机构：

[1] China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang 110004, Peoples R China

[2] Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China

[3] Natl Res Inst Family Planning, Beijing 100081, Peoples R China

[4] World Hlth Org Collaborating Ctr Res Human Reprod, Beijing 100081, Peoples R China

来源：

WORLD JOURNAL OF PEDIATRICS | 2013年 / 9卷 / 03期

关键词：

congenital heart disease; genetics; HHEX; transcription factor; HOMEOBOX GENE; EMBRYONIC ENDODERM; HEX; XENOPUS; CELLS;

D O I：

10.1007/s12519-013-0430-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The hematopoietically expressed homeobox (HHEX) gene is an important determinant of mammalian heart development. This study aimed to identify the potential mutations of the gene in Chinese patients with congenital heart disease (CHD). We collected 296 CHD patients and 200 controls, and classified the cardiac deformities. Then we conducted sequence analyses of the HHEX gene in those patients. In all the CHD patients, we did not find any causative mutations in the coding region of the HHEX gene. To our knowledge, this is the first study to examine the HHEX gene in non-symptomatic CHD cases, and this has expanded our knowledge about its etiology.

引用

页码：278 / 280

页数：3

共 50 条

[41] Brain pathology in patients with congenital heart disease
Alturkustani, Murad
Szymanski, Linda J.
FOLIA NEUROPATHOLOGICA, 2023, 61 (01) : 16 - 24
[42] eHealth in patients with congenital heart disease: a review
Kauw, Dirkjan
Koole, M. A. C.
van Dorth, Jolien R.
Tulevski, Igor I.
Somsen, G. Aernout
Schijven, Marlies P.
Dohmen, Daan A. J.
Bouma, Berto J.
Mulder, Barbara J. M.
Schuuring, Mark J.
Winter, Michiel M.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY, 2018, 16 (09) : 627 - 634
[43] Workplace Harassment in Patients with Congenital Heart Disease
Martínez-Quintana E.
Déniz-Alvarado B.
Gallego-Sosa C.
Pardo-Maiza J.
González-Martín J.M.
Rodríguez-González F.
International Journal of Bullying Prevention, 2025, 7 (1) : 36 - 44
[44] Anesthesia in adult patients with congenital heart disease
Cannesson, Maxime
Collange, Vincent
Lehot, Jean-Jacques
CURRENT OPINION IN ANESTHESIOLOGY, 2009, 22 (01) : 88 - 94
[45] PREGNANCY IN PATIENTS WITH CONGENITAL HEART-DISEASE
SCHLEMMER, M
WIENER KLINISCHE WOCHENSCHRIFT, 1995, 107 (20) : 608 - 612
[46] Outcomes of Aortopexy for Patients With Congenital Heart Disease
Sang-Yun Lee
Soo-Jin Kim
Jae-Suk Baek
Jae-Gun Kwak
Chul Lee
Chang-Ha Lee
Yang-Min Kim
Pediatric Cardiology, 2013, 34 : 1469 - 1475
[47] Outcomes of Aortopexy for Patients With Congenital Heart Disease
Lee, Sang-Yun
Kim, Soo-Jin
Baek, Jae-Suk
Kwak, Jae-Gun
Lee, Chul
Lee, Chang-Ha
Kim, Yang-Min
PEDIATRIC CARDIOLOGY, 2013, 34 (06) : 1469 - 1475
[48] Regenerative Therapy for Patients with Congenital Heart Disease
Kimura, Naritaka
KEIO JOURNAL OF MEDICINE, 2019, 68 (02): : 29 - 38
[49] Berlin Heart EXCOR use in patients with congenital heart disease
Morales, David L. S.
Zafar, Farhan
Almond, Christopher S.
Canter, Charles
Fynn-Thompson, Francis
Conway, Jennifer
Adachi, Iki
Lorts, Angela
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2017, 36 (11): : 1209 - 1216
[50] Increasing Complexity of Heart Transplantation in Patients With Congenital Heart Disease
Shi, William Y.
Saxena, Pankaj
Yong, Matthew S.
Marasco, Silvana F.
McGiffin, David C.
Shipp, Anne
Weintraub, Robert G.
d'Udekem, Yves
Brizard, Christian P.
Konstantinov, Igor E.
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY, 2016, 28 (02) : 487 - 497

← 1 2 3 4 5 →