The HHEX gene is not related to congenital heart disease in 296 Chinese patients

被引：2

作者：

Deng, Xiao-Peng ^{[1
]}

Zhao, Li-Xi ^{[2
,3
]}

Wang, Bin-Bin ^{[2
,3
]}

Wang, Jing ^{[2
,3
]}

Cheng, Long-Fei ^{[2
,3
]}

Cheng, Zhi ^{[2
,3
]}

Suo, Pei-Su ^{[2
,3
]}

Li, Hui ^{[1
]}

Ma, Xu ^{[2
,3
,4
]}

机构：

[1] China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang 110004, Peoples R China

[2] Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China

[3] Natl Res Inst Family Planning, Beijing 100081, Peoples R China

[4] World Hlth Org Collaborating Ctr Res Human Reprod, Beijing 100081, Peoples R China

来源：

WORLD JOURNAL OF PEDIATRICS | 2013年 / 9卷 / 03期

关键词：

congenital heart disease; genetics; HHEX; transcription factor; HOMEOBOX GENE; EMBRYONIC ENDODERM; HEX; XENOPUS; CELLS;

D O I：

10.1007/s12519-013-0430-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The hematopoietically expressed homeobox (HHEX) gene is an important determinant of mammalian heart development. This study aimed to identify the potential mutations of the gene in Chinese patients with congenital heart disease (CHD). We collected 296 CHD patients and 200 controls, and classified the cardiac deformities. Then we conducted sequence analyses of the HHEX gene in those patients. In all the CHD patients, we did not find any causative mutations in the coding region of the HHEX gene. To our knowledge, this is the first study to examine the HHEX gene in non-symptomatic CHD cases, and this has expanded our knowledge about its etiology.

引用

页码：278 / 280

页数：3

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