Synthesis and characterization of chitosan-based hydrogels

被引：61

作者：

Li, Qianzhu ^{[1
,2
]}

Yang, Dongzhi ^{[1
,2
]}

Ma, Guiping ^{[1
,2
]}

Xu, Qiang ^{[3
]}

Chen, Xiangmei ^{[3
]}

Lu, Fengmin ^{[3
]}

Nie, Jun ^{[1
,2
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

[2] Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China

[3] Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2009年 / 44卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Biocompatible; Chitosan; Photocrosslinking; DRUG-DELIVERY; CROSS-LINKING; COPOLYMERS; MEMBRANE;

D O I：

10.1016/j.ijbiomac.2008.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biocompatible hydrogels based on water-soluble chitosan-ethylene glycol acrylate methacrylate (CS-EGAMA) and polyethylene glycol diamethacrylate (PEGDMA) were synthesized by photopolymerization. Characterization of morphology, weight loss, water state of hydrogel, pH-sensitivity and cytotoxicity were investigated by scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), swelling test and methylthiazolydiphenyl-tetrazolium bromide (MTT) assay. The results indicated that the hydrogels were sensitive to pH of the medium, no cytotoxicity for L929 and SW1353, satisfactory for the composite to be used in bioapplications. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：121 / 127

页数：7

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