Application of scaffolds for bone regeneration strategies: Current trends and future directions

被引：72
作者：
Billstrom, Gry Hulsart [1 ]
Blom, Ashley W. [2 ]
Larsson, Sune [1 ]
Beswick, Andrew D. [2 ]
机构：
[1] Uppsala Univ, Dept Orthoped, S-75681 Uppsala, Sweden
[2] Univ Bristol, Musculoskeletal Res Unit, Bristol BS8 1TH, Avon, England
来源：
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2013年 / 44卷
关键词：
Scaffolds; Bone regeneration; Preclinical studies; Clinical applications; BETA-TRICALCIUM PHOSPHATE; TIBIAL PLATEAU FRACTURES; TOTAL HIP-ARTHROPLASTY; IN-VITRO; CALCIUM PHOSPHATES; FOLLOW-UP; POSTEROLATERAL FUSION; STRONTIUM RANELATE; ACETABULAR BONE; MARROW ASPIRATE;
D O I：
10.1016/S0020-1383(13)70007-X
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Scaffolds are extensively used in surgery to replace missing bone and to achieve bony union and fusion. An ideal scaffold should not only maintain, induce, and restore biological functions where cells, extracellular matrix, and growth factors are needed, but also have the right properties with respect to degradation, cell binding, cellular uptake, non-immunogenicity, mechanical strength, and flexibility. Here we examine both the basic science behind the development of scaffolds and comprehensively and systematically review the clinical applications. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：S28 / S33
页数：6
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