Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment

被引：26

作者：

Jrad-Lamine, Aicha ^{[1
,6
]}

Henry-Berger, Joelle ^{[1
]}

Damon-Soubeyrand, Christelle ^{[1
]}

Saez, Fabrice ^{[1
]}

Kocer, Ayhan ^{[1
]}

Janny, Laurent ^{[1
,2
]}

Pons-Rejraji, Hanae ^{[1
,2
]}

Munn, David H. ^{[3
,4
]}

Mellor, Andrew L. ^{[3
,5
]}

Gharbi, Najoua ^{[6
]}

Cadet, Remi ^{[1
]}

Guiton, Rachel ^{[1
]}

Aitken, Robert J. ^{[7
]}

Drevet, Joel R. ^{[1
]}

机构：

[1] Clermont Univ, INSERM, CNRS, GReD Lab,U1103,UMR 6293, Aubiere, France

[2] CECOS, CHU Estaing, Clermont Ferrand, France

[3] Med Coll Georgia, Immunotherapy Ctr, Augusta, GA 30912 USA

[4] Med Coll Georgia, Dept Pediat, Augusta, GA 30912 USA

[5] Med Coll Georgia, Dept Med, Augusta, GA 30912 USA

[6] Fac Sci Tunis, Dept Biol, Tunis 1060, Tunisia

[7] Univ Newcastle, Prior Res Ctr Reprod Sci, Sch Environm & Life Sci, Callaghan, NSW 2308, Australia

来源：

PLOS ONE | 2013年 / 8卷 / 06期

关键词：

REGULATORY T-CELLS; POLYUNSATURATED FATTY-ACIDS; TRYPTOPHAN CATABOLISM; DENDRITIC CELLS; TGF-BETA; EXPRESSION; TOLERANCE; INFLAMMATION; CYCLOOXYGENASE-1; LEPTIN;

D O I：

10.1371/journal.pone.0066494

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1(-/-) model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1(-/-) animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed.

引用

页数：13

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