Frequent Presence of Lymphovascular Invasion in Small Rectal Neuroendocrine Tumors on Immunohistochemical Analysis

被引：2

作者：

Kitagawa, Yoshiyasu ^{[1
]}

Ikebe, Dai ^{[2
]}

Suzuki, Takuto ^{[1
]}

Hara, Taro ^{[1
]}

Itami, Makiko ^{[2
]}

Yamaguchi, Taketo ^{[3
]}

机构：

[1] Chiba Canc Ctr, Endoscopy Div, Chiba, Japan

[2] Chiba Canc Ctr, Div Surg Pathol, Chiba, Japan

[3] Chiba Canc Ctr, Dept Gastroenterol, Chiba, Japan

来源：

DIGESTION | 2017年 / 95卷 / 01期

关键词：

Lymphovascular invasion; Rectal neuroendocrine tumors; Endoscopic resection; Immunohistochemical analysis; ENDOSCOPIC SUBMUCOSAL DISSECTION; LOW ANTERIOR RESECTION; CARCINOID-TUMORS; INTERSPHINCTERIC RESECTION; CONSENSUS GUIDELINES; MUCOSAL RESECTION; LIGATION DEVICE; CANCER; MANAGEMENT; PROGNOSIS;

D O I：

10.1159/000452357

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Rectal neuroendocrine tumors (RNETs) have become common in recent years and are good candidates for endoscopic resection (ER). To achieve clear resection margins, more advanced techniques such as endoscopic submucosal dissection, endoscopic submucosal resection with a ligation device, and cap-assisted endoscopic mucosal resection are available for ER. After ER, lymphovascular invasion (LVI) is regarded as an important predictor of nodal metastasis. Previous studies have shown that small RNETs with LVI were uncommon (0-8.3%). However, using immunohistochemical analysis, a recent study revealed the frequent occurrence of LVI in small RNETs in a systematic manner (46.7%). There is a possibility that the actual detection rate of LVI in small RNETs is not always evaluated accurately because of the limited detection sensitivity of conventional hematoxylin-eosin staining. In addition, the correlation between LVI detected using immunohistochemical analysis and the development of metastasis remains unclear. Further prospective studies are required to clarify the role of LVI detected using immunohistochemical analysis. (C) 2016 S. Karger AG, Basel

引用

页码：16 / 21

页数：6

共 35 条

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