Prenatal inflammation and neurodevelopment in schizophrenia: A review of human studies

被引：91

作者：

Miller, Brian J. ^{[1
]}

Culpepper, Nickolas ^{[2
]}

Rapaport, Mark H. ^{[3
]}

Buckley, Peter ^{[2
]}

机构：

[1] Georgia Hlth Sci Univ, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA

[2] Georgia Hlth Sci Univ, Sch Med, Augusta, GA 30912 USA

[3] Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2013年 / 42卷

关键词：

Cytokines; Infection; Inflammation; Neurodevelopment; Pregnancy; Schizophrenia; VARIANTS CONFERRING RISK; IMMUNE ACTIVATION; BRAIN-DEVELOPMENT; COMMON VARIANTS; INTERLEUKIN-8; LEVELS; INTRAUTERINE GROWTH; CYTOKINE LEVELS; FETAL EXPOSURE; PRETERM LABOR; ANIMAL-MODELS;

D O I：

10.1016/j.pnpbp.2012.03.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A confluence of evidence supports an association between prenatal inflammation and risk of schizophrenia. Outside of studies of prenatal infections and risk of schizophrenia, other relevant human studies of prenatal inflammation and neurodevelopment in schizophrenia have not been reviewed. In this paper, we review human studies of 1) prenatal inflammation and risk of schizophrenia, 2) inflammation as a potential common mediator of several prenatal risk factors for schizophrenia other than prenatal infections, 3) prenatal inflammation and immune function, neurocognition, brain morphology, and gene expression in adult offspring with schizophrenia, and 4) gene by environment and gene by gene interactions relevant to these associations. We suggest future areas for human studies research based on existing findings. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：92 / 100

页数：9

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