Role of extracellular matrix on colonic cancer cell migration and proliferation

被引：30

作者：

Ohtaka, K ^{[1
]}

Watanabe, S ^{[1
]}

Iwazaki, R ^{[1
]}

Hirose, M ^{[1
]}

Sato, N ^{[1
]}

机构：

[1] JUNTENDO UNIV,SCH MED,DEPT GASTROENTEROL,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 220卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.0408

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simplified method to quantitatively analyze the migration and proliferative capacity of a colonic cancer cell line (SW837) in vitro was developed. The objective of this study was to evaluate the role of the extracellular matrix in colon cancer metastasis. We used this model to investigate the effects of the extracellular matrix components collagen type I and type IV, laminin, and fibronectin on the migration and the proliferation of cancer cells. Migration was fastest on laminin and slowest on collagen type I. Further, proliferation was highest on laminin of all extracellular matrices groups studied. Therefore, it is concluded that laminin had pronounced effects on migration and proliferation of SW837 cells. These findings suggest that the composition of the extracellular matrix plays an important role in the mechanism of metastasis of colon cancer cells. (C) 1996 Academic Press, Inc.

引用

页码：346 / 352

页数：7

共 27 条

[1]

ALBINI A, 1987, CANCER RES, V47, P3239

[2]

ALBRECHTBUEHLER G, 1977, CELL, V11, P359

[3] STRUCTURALLY DISTINCT COLLAGEN TYPES [J].

BORNSTEIN, P ;

SAGE, H .

ANNUAL REVIEW OF BIOCHEMISTRY, 1980, 49 :957-1003

[4] CELL-SURFACE RECEPTORS FOR EXTRACELLULAR-MATRIX MOLECULES [J].

BUCK, CA ;

HORWITZ, AF .

ANNUAL REVIEW OF CELL BIOLOGY, 1987, 3 :179-205

[5] INTEGRINS AND TUMOR INVASION [J].

DEDHAR, S .

BIOESSAYS, 1990, 12 (12) :583-590

[6]

FRIDMAN R, 1993, ADV MOL CELL BIOL, V6, P253

[7] MONOCLONAL-ANTIBODY TO 5-BROMODEOXYURIDINE AND 5-IODODEOXYURIDINE - A NEW REAGENT FOR DETECTION OF DNA-REPLICATION [J].

GRATZNER, HG .

SCIENCE, 1982, 218 (4571) :474-475

[8]

HARALSON MA, 1993, LAB INVEST, V69, P369

[9] A SYNTHETIC PEPTIDE FROM FIBRONECTIN INHIBITS EXPERIMENTAL METASTASIS OF MURINE MELANOMA-CELLS [J].

HUMPHRIES, MJ ;

OLDEN, K ;

YAMADA, KM .

SCIENCE, 1986, 233 (4762) :467-470

[10] EXPRESSION OF SEVERAL GROWTH-FACTORS AND THEIR RECEPTOR GENES IN HUMAN COLON CARCINOMAS [J].

ITO, M ;

YOSHIDA, K ;

KYO, E ;

AYHAN, A ;

NAKAYAMA, H ;

YASUI, W ;

ITO, H ;

TAHARA, E .

VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1990, 59 (03) :173-178

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