Room temperature Au(I)-catalyzed exo-selective cycloisomerization of acetylenic acids:: An entry to functionalized γ-lactones

被引：238

作者：

Genin, E ^{[1
]}

Toullec, PY ^{[1
]}

Antoniotti, S ^{[1
]}

Brancour, C ^{[1
]}

Genêt, JP ^{[1
]}

Michelet, V ^{[1
]}

机构：

[1] ENSCP, Lab Synth Select Organ & Prod Nat, UMR 7573, F-75231 Paris 05, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 10期

关键词：

D O I：

10.1021/ja056857j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient gold-catalyzed cyclization reaction of various functionalized acetylenic acids is described. The cyclizations are conducted in the presence of Au(I) catalyst in acetonitrile at room temperature in a short reaction time. The reaction conditions are compatible with several functional groups, such as ester, alkene, alkyne, chloro, and free or protected alcohol, and lead to original γ-lactones in good to excellent yields. Copyright © 2006 American Chemical Society.

引用

页码：3112 / 3113

页数：2

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