4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter

被引：16

作者：

Hulubei, Victoria ^{[1
]}

Meikrantz, Scott B. ^{[1
]}

Quincy, David A. ^{[1
]}

Houle, Tina ^{[1
]}

McKenna, John I. ^{[1
]}

Rogers, Mark E. ^{[1
]}

Steiger, Scott ^{[2
]}

Natale, N. R. ^{[1
,2
]}

机构：

[1] Univ Idaho, Dept Chem, Moscow, ID 83844 USA

[2] Univ Montana, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 22期

关键词：

Isoxazole; Dihydropyridine; Multidrug transporter; Adjuvant; Lateral metalation; LATERAL METALATION; DIHYDROPYRIDINE DERIVATIVES; ISOXAZOLES; MODIFIERS; UTILITY;

D O I：

10.1016/j.bmc.2012.09.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 4-isoxazolyl-dihydropyridines (IDHPs) exhibit inhibition of the multidrug-resistance transporter (MDR-1), and exhibit an SAR distinct from their activity at voltage gated calcium channels (VGCC). Among the four most active IDHPs, three were branched at C-5 of the isoxazole, including the most active analog, 1k. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6613 / 6620

页数：8

共 36 条

[1] Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [J].