Vasorelaxant Prenylated Flavonoids from the Roots of Sophora flavescens

被引：13

作者：

Kim, Chul Young ^{[1
]}

Kim, Hyun Jung ^{[2
]}

Kim, Kyeong-Man ^{[3
]}

Oak, Min-Ho ^{[2
]}

机构：

[1] Hanyang Univ, Coll Pharm, Ansan 426791, Kyeonggi Do, South Korea

[2] Mokpo Natl Univ, Coll Pharm, Muan Gun 534729, Jeollanam Do, South Korea

[3] Chonnam Natl Univ, Dept Pharmacol, Drug Dev Res Ctr, Coll Pharm, Kwangju 500757, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 02期

关键词：

vasorelaxation activity; Sophora flavescens; prenylated flavonoid; kushenol N; 5-methylsophoraflavanone B; BIOLOGICAL EVALUATION; AGENTS; FLAVANONES; MECHANISM; EXTRACT;

D O I：

10.1271/bbb.120739

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioassay-guided fractionation of the methanol extract from the root of Sophora flaivscens led to the isolation of eight known prenylated flavonoids responsible for the vasorelaxation activity in porcine coronary arteries. Among them, kushenol N and 5-methylsophoraflavanone B strongly induced the relaxation of porcine coronary arteries with respective ED50 values of 8.6 and 12.4 mu m. This activity and the results of a high-performance liquid chromatographic analysis suggest that kushenol N and 5-methylsophoraflavanone B could be active markers in the S. flavescens extract for vasorelaxation activity.

引用

页码：395 / 397

页数：3

共 15 条

[1]

Anselm E, 2005, FASEB J, V19, pA1230

[2] The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties [J].