Hollow magnetic hydroxyapatite microspheres with hierarchically mesoporous microstructure for pH-responsive drug delivery

被引：65

作者：

Lin, Kaili ^{[1
]}

Chen, Lei ^{[1
]}

Liu, Peiyi ^{[2
]}

Zou, Zhaoyong ^{[1
]}

Zhang, Meili ^{[1
]}

Shen, Yuhui ^{[2
]}

Qiao, Yuqin ^{[1
]}

Liu, Xuanyong ^{[1
]}

Chang, Jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Ruijin Hosp, Sch Med, Shanghai Inst Orthopaed & Traumatol,Dept Orthopae, Shanghai, Peoples R China

来源：

CRYSTENGCOMM | 2013年 / 15卷 / 15期

关键词：

ENCAPSULATED GAMMA-FE2O3 NANOCRYSTALLITES; SUBSTITUTED HYDROXYAPATITE; SURFACTANT-FREE; HETEROGENEOUS CATALYST; DOPED HYDROXYAPATITE; NANOPARTICLES; BONE; ADSORPTION; PARTICLES; APATITES;

D O I：

10.1039/c3ce26683d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The hollow magnetic hydroxyapatite [Ca-10(PO4)(6)(OH)(2), HAp] microspheres with hierarchically mesoporous structures were hydrothermally fabricated using the similar structured CaCO3/Fe3O4 hollow microspheres as the sacrificial hard-templates. The magnetic property, in vitro biocompatibility, drug loading and release properties in different pH solutions were further investigated. The results showed that the magnetic properties for these biocompatible HAp microspheres could be well adjusted by modulation of the Fe3O4 amount, and the drug release rate increased apparently with the decrease of the pH values of the solution medium. The high drug-loading capacity and sustained drug release property suggest that the fabricated multifunctional hollow microspheres have great potential for magnetic and pH responsive drug-delivery applications.

引用

页码：2999 / 3008

页数：10

共 58 条

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