Sry and sex determination:: how lazy can it be?

被引：39

作者：

Canning, CA ^{[1
]}

Lovell-Badge, R ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Dev Genet, London NW7 1AA, England

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0168-9525(01)02615-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sry is at the top of the cascade of genetic activity leading to male development in mammals. It does not have to work hard, however, to maintain its position. A quick burst of activity of this Winked gene at the right time is all that is needed to trigger the downstream events. But does SRY act on a single or several downstream targets? Recent data can be used to argue that SRY has only one critical downstream target, Sox9. However, we should be a little careful before jumping to this conclusion.

引用

页码：111 / 113

页数：3

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