Down Syndrome with Different Hematological Manifestations: A Short Series of 3 Cases with Review of Literature

被引：4

作者：

Manivannan, Prabhu ^{[1
]}

Prasaad, Priavadhana Rajan ^{[1
]}

Kar, Rakhee ^{[1
]}

Basu, Debdatta ^{[1
]}

机构：

[1] JIPMER, Dept Pathol, Pondicherry 605006, India

来源：

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION | 2013年 / 29卷 / 01期

关键词：

Down syndrome; Transient myeloproliferative disorder; Acute myeloid leukemia; Acute megakaryoblastic leukemia; TRANSIENT MYELOPROLIFERATIVE DISORDER; NATURAL-HISTORY; LEUKEMIA; TRISOMY-21; CHILDREN; GATA1;

D O I：

10.1007/s12288-011-0134-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Children with Down syndrome (DS) present with a spectrum of hematolymphoid malignancies ranging from transient myeloproliferative disorder (TMD) which regress spontaneously to frank acute leukemia of both myeloid and lymphoid lineage. Here we present a series of three cases with different manifestation in DS. Three cases of DS presented with TMD, acute myeloid leukemia (AML-M2) and acute megakaryoblastic leukemia (AMKL), respectively. This case series displays the spectrum of hematological manifestations in children with DS. Although TMD and AMKL are strongly associated with DS, other AML subtypes can also be seen in such patients.

引用

页码：31 / 34

页数：4

共 12 条

[1] Natural history of GATA1 mutations in Down syndrome [J].

Ahmed, M ;

Sternberg, A ;

Hall, G ;

Thomas, A ;

Smith, O ;

O'Marcaigh, A ;

Wynn, R ;

Stevens, R ;

Addison, M ;

King, D ;

Stewart, B ;

Gibson, B ;

Roberts, I ;

Vyas, P .

BLOOD, 2004, 103 (07) :2480-2489

[2]

Aier Moatoshi, 2002, Indian J Pathol Microbiol, V45, P355

[3]

Baumann I., 2008, WHO classsification of tumours of haematopoietic and lymphoid tissues, P142

[4] TRANSIENT LEUKEMIA WITH TRISOMY-21 - DESCRIPTION OF A CASE AND REVIEW OF THE LITERATURE [J].

BHATT, S ;

SCHRECK, R ;

GRAHAM, JM ;

KORENBERG, JR ;

HURVITZ, CG ;

FISCHELGHODSIAN, N .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1995, 58 (04) :310-314

[5] GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia [J].

Ge, YB ;

Stout, ML ;

Tatman, DA ;

Jensen, TL ;

Buck, SA ;

Thomas, RL ;

Ravindranath, Y ;

Matherly, LH ;

Taub, JW .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (03) :226-231

[6]

HOMANS AC, 1993, AM J PEDIAT HEMATOL, V15, P392

[7]

Karandikar NJ, 2001, AM J CLIN PATHOL, V116, P204

[8] A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481 [J].

Massey, Gita V. ;

Zipursky, Alvin ;

Chang, Myron N. ;

Doyle, John J. ;

Nasim, Suhail ;

Taub, Jeffrey W. ;

Ravindranath, Yaddanapudi ;

Dahl, Gary ;

Weinstein, Howard J. .

BLOOD, 2006, 107 (12) :4606-4613

[9] Malignancy in Children with Trisomy 21 [J].

Rabin, Karen R. ;

Whitlock, James A. .

ONCOLOGIST, 2009, 14 (02) :164-173

[10] Down's syndrome [J].

Roizen, NJ ;

Patterson, D .

LANCET, 2003, 361 (9365) :1281-1289

← 1 2 →