Development of new linkers for the formation of aliphatic C-H bonds on polymeric supports

被引：27
作者：
Jung, KW
Zhao, XY
Janda, KD
机构：
[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA
[2] SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA
来源：
TETRAHEDRON | 1997年 / 53卷 / 19期
关键词：
D O I：
10.1016/S0040-4020(97)00222-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two polmyeric linkers, 8 and II, were prepared in high yields. Attachment of an alkyl group to these linkers was facile, and their cleavage from the MeO-PEG polymer support was accomplished by desulfurization using Raney nickel to yield the new carbon-hydrogen bond product 6. The protocol reponed herein allows efficient preparation of new polymeric linkers as well as their possible application to combinatorial libraries. (C) 1997 Published by Elsevier Science Ltd.
引用
收藏
页码：6645 / 6652
页数：8
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