Synthesis and micellar characterization of novel pH-sensitive thiol-ended triblock copolymer via combination of RAFT and ROP processes

被引：11

作者：

Sofla, Somayyeh Fallah Iri ^{[1
]}

Abbasian, Mojtaba ^{[2
]}

Mirzaei, Mortaza ^{[1
,2
]}

机构：

[1] Islamic Azad Univ, Miyaneh Branch, Dept Chem Organ Chem, Miyaneh, Iran

[2] Payame Noor Univ, Dept Chem, POB 19395-3697, Tehran, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2019年 / 68卷 / 06期

基金：

美国国家科学基金会;

关键词：

de novo drug delivery; pH-responsive; raft polymerization; self-assembly; triblock copolymer; DRUG-DELIVERY; CONTROLLED-RELEASE; BLOCK-COPOLYMERS; ACID; POLYMERIZATION; NANOCOMPOSITE; TEMPERATURE; MICROGELS; POLYMERS;

D O I：

10.1080/00914037.2018.1445630

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A new pH- sensitive thiol-ended amphiphilic triblock copolymer was synthesized by reversible addition fragmentation chain transfer polymerization. The critical micelle concentration (CMC) value for the synthesized PAA-b-PDMAEMAQ-b-PCL-SH triblock copolymer was determined to be 0.0079 g L-1 using fluorescence probe technique. The average sizes of PAA-b-PDMAEMAQ-b-PCL-SH micelles was obtained to be 30 +/- 5 nm using TEM observation. It is expected that the synthesized PAA-b-PDMAEMAQ-b-PCL-SH triblock copolymer considered as a prospective candidate in nanomedicine applications such as chemo-photothermal therapy and drug delivery, mainly due to the strong affinity of thiol-ended group toward gold nanoparticle and its excellent micellization behavior.

引用

页码：297 / 307

页数：11

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