Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival

被引：30

作者：

Galleu, Antonio ^{[1
,2
]}

Milojkovic, Dragana ^{[3
]}

Deplano, Simona ^{[3
]}

Szydlo, Richard ^{[4
]}

Loaiza, Sandra ^{[3
]}

Wynn, Robert ^{[5
]}

Marks, David I. ^{[6
]}

Richardson, Deborah ^{[7
]}

Orchard, Kim ^{[7
]}

Kanfer, Edward ^{[3
]}

Tholouli, Eleni ^{[5
]}

Saif, Muhammad ^{[5
]}

Sivaprakasam, Ponni ^{[6
]}

Lawson, Sarah ^{[8
]}

Bloor, Adrian ^{[9
]}

Pagliuca, Antonio ^{[10
]}

Potter, Victoria ^{[10
]}

Mehra, Varun ^{[10
]}

Snowden, John A. ^{[11
]}

Vora, Ajay ^{[12
]}

Kishore, Bhuvan ^{[13
]}

Hunter, Hannah ^{[14
]}

Apperley, Jane F. ^{[3
,4
]}

Dazzi, Francesco ^{[1
,2
,3
,4
]}

机构：

[1] Kings Coll London, London, England

[2] Kings Hlth Partners Canc Res UK Ctr, London, England

[3] Imperial Coll Healthcare NHS Trust, London, England

[4] Imperial Coll London, London, England

[5] Cent Manchester Univ Hosp, Manchester, Lancs, England

[6] Univ Hosp Bristol, Bristol, Avon, England

[7] Southampton Univ Hosp, Southampton, Hants, England

[8] Birmingham Womens & Childrens Hosp, Birmingham, W Midlands, England

[9] Christie NHS Fdn Trust, Manchester, Lancs, England

[10] Kings Coll Hosp NHS Trust, London, England

[11] Sheffield Teaching Hosp NHS Fdn Trust, Sheffield, S Yorkshire, England

[12] Sheffield Childrens Hosp, Sheffield, S Yorkshire, England

[13] NHS Fdn Trust, Heart England, Birmingham, W Midlands, England

[14] Plymouth Hosp NHS Trust, Plymouth, Devon, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2019年 / 185卷 / 01期

关键词：

cellular therapies; GvHD; mesenchymal cells; clinical research; stromal cells; STEM-CELLS; STEROID-RESISTANT; ACUTE GVHD; GRADE III; THERAPY;

D O I：

10.1111/bjh.15749

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mesenchymal stromal cells (MSCs) have been successfully used for the treatment of steroid-resistant graft-versus-host-disease (GvHD). However, the lack of early predictors of clinical responses impacts on the time at which to add further treatment and consequently the design of informative clinical trials. Here, we present the UK experience of one of the largest cohorts of GvHD patients undergoing MSC infusions so far reported. We show that clinical responses assessed as early as 1 week after MSC infusion predict patients' overall survival. In our cohort, cell dose, patients' age and type of organ involvement are crucial factors associated with clinical responses.

引用

页码：89 / 92

页数：4

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