Significance of Clinicopathology and Expression of Heat Shock Protein 72 in Human Primary Lung Carcinomas

被引：1

作者：

Fang, Yan ^{[1
]}

Wang, XiaoPing ^{[1
,2
]}

Lin, HuanPing ^{[1
]}

Wang, QiaoXia ^{[3
]}

机构：

[1] Shaanxi Univ Chinese Med, Xianyang 712046, Peoples R China

[2] North Dakota State Univ, Fargo, ND 58102 USA

[3] Xi An Jiao Tong Univ, Dept Infect Dis, Xian 710003, Peoples R China

来源：

ADVANCED RESEARCH ON INDUSTRY, INFORMATION SYSTEM AND MATERIAL ENGINEERING | 2012年 / 459卷

基金：

中国国家自然科学基金;

关键词：

heat shock protein 72(HSP72); glycoprotein 96(gp96); primary lung carcinoma; clinicopathology; prognosis; CELLS; CANCER; HSP70; CHAPERONE; P53; HEAT-SHOCK-PROTEIN-72; GLYCOPROTEIN-96; ADENOCARCINOMA; ACTIVATION; STRESS;

D O I：

10.4028/www.scientific.net/AMR.459.242

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of lung carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 and gp96 in human lung carcinoma. Immunohistochemistry demonstrated that HSP72 and gp96 expression in lung carcinomas with metastasis was significantly higher than those with non-metastasis. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.

引用

页码：242 / +

页数：3

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