Mesenchymal Stem Cells: An Emerging Tool for Cancer Targeting and Therapy

被引:69
作者
Fritz, Vanessa [1 ,2 ]
Jorgensen, Christian [1 ,2 ,3 ]
机构
[1] CHU Hop St Eloi, INSERM, U844, F-34091 Montpellier 5, France
[2] Univ Montpellier I, UFR Med, F-34000 Montpellier, France
[3] CHU Lapeyronie, Unite Clin Immunorhumatol Therapeut Malad Articul, F-34295 Montpellier, France
关键词
Mesenchymal stem cells; bone-marrow; cell-mediated gene therapy; migration; tumor-tropism; cancer therapy;
D O I
10.2174/157488808783489462
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Mesenchymal stem cells (MSCs) from post-natal bone marrow possess tremendous potential for cell-mediated gene therapy in several disease processes, and recent reports have broadened the spectrum for therapeutic applications to cancer therapy. The evidence that sites of active tumorigenesis favor the homing of exogenous MSCs have support the rationale for developing engineered MSCs as a tool to track malignant tissues and deliver anticancer agents within the tumor microenvironment. Several reports have proven the efficiency of MSCs as cell carrier for in vivo delivery of various clinically relevant anticancer factors, including cytokines, interferon, pro-drugs or replicative adenovirus, and tumor growth inhibition following engraftment within or in the vicinity of tumor. The enthusiasm for MSCs is further reinforced by the striking observation that unmodified MSCs can exert antitumorigenic activity, and preliminary reports in immunocompetent animals have provided encouraging results for the use of MSCs in cancer immunotherapy. This review highlights recent works and potential clinical applications of MSCs in this field.
引用
收藏
页码:32 / 42
页数:11
相关论文
共 133 条
[31]   A neovascularized organoid derived from retrovirally engineered bone marrow stroma leads to prolonged in vivo systemic delivery of erythropoietin in nonmyeloablated, immunocompetent mice [J].
Eliopoulos, N ;
Al-Khaldi, A ;
Crosato, M ;
Lachapelle, K ;
Galipeau, J .
GENE THERAPY, 2003, 10 (06) :478-489
[32]   Anti-tumor activity of mesenchymal stem cells producing IL-12 in a mouse melanoma model [J].
Elzaouk, Lina ;
Moelling, Karin ;
Pavlovic, Jovan .
EXPERIMENTAL DERMATOLOGY, 2006, 15 (11) :865-874
[33]   Mesenchymal progenitor cells in human umbilical cord blood [J].
Erices, A ;
Conget, P ;
Minguell, JJ .
BRITISH JOURNAL OF HAEMATOLOGY, 2000, 109 (01) :235-242
[34]   Muscle regeneration by bone marrow derived myogenic progenitors [J].
Ferrari, G ;
Cusella-De Angelis, G ;
Coletta, M ;
Paolucci, E ;
Stornaiuolo, A ;
Cossu, G ;
Mavilio, F .
SCIENCE, 1998, 279 (5356) :1528-1530
[35]   BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells [J].
Fiedler, J ;
Röderer, G ;
Günther, KP ;
Brenner, RE .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, 87 (03) :305-312
[36]   IGF-I and IGF-II stimulate directed cell migration of bone-marrow-derived human mesenchymal progenitor cells [J].
Fiedler, Joerg ;
Brill, Caroline ;
Blum, Werner F. ;
Brenner, Rolf E. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 345 (03) :1177-1183
[37]   Hepatocyte growth factor effects on mesenchymal stem cells: Proliferation, migration, and differentiation [J].
Forte, G ;
Minieri, M ;
Cossa, P ;
Antenucci, D ;
Sala, M ;
Gnocchi, V ;
Fiaccavento, R ;
Carotenuto, F ;
De Vito, P ;
Baldini, PM ;
Prat, M ;
Di Nardo, P .
STEM CELLS, 2006, 24 (01) :23-33
[38]   Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs:: A study of their quantitative distribution after irradiation damage [J].
Francois, Sabine ;
Bensidhoum, Morad ;
Mouiseddine, Moubarak ;
Mazurier, Christelle ;
Allenet, Benedicte ;
Semont, Alexandra ;
Frick, Johanna ;
Sache, Aniandine ;
Bouchet, Sandrine ;
Thierry, Dominique ;
Goumelon, Patrick ;
Gorin, Norbert-Claude ;
Chapel, Alain .
STEM CELLS, 2006, 24 (04) :1020-1029
[39]   HETEROTOPIC TRANSPLANTS OF BONE MARROW - ANALYSIS OF PRECURSOR CELLS FOR OSTEOGENIC AND HEMATOPOIETIC TISSUES [J].
FRIEDENSTEIN, AJ ;
PETRAKOVA, KV ;
KUROLESOVA, AI ;
FROLOVA, GP .
TRANSPLANTATION, 1968, 6 (02) :230-+
[40]   Micro-CT combined with bioluminescence imaging:: A dynamic approach to detect early tumor-bone interaction in a tumor osteolysis murine model [J].
Fritz, Vanessa ;
Louis-Plence, Pascale ;
Apparailly, Florence ;
Noel, Danile ;
Voide, Romain ;
Pillon, Arnaud ;
Nicolas, Jean-Claude ;
Mueller, Ralph ;
Jorgensen, Christian .
BONE, 2007, 40 (04) :1032-1040