A photo-responsive cholesterol capable of inducing a morphological transformation of the liquid-ordered microdomain in lipid bilayers

被引：17

作者：

Yasuhara, Kazuma ^{[1
]}

Sasaki, Yoshihiro ^{[1
]}

Kikuchi, Jun-ichi ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 6300192, Japan

来源：

COLLOID AND POLYMER SCIENCE | 2008年 / 286卷 / 14-15期

关键词：

Liquid-ordered domain; Lipid raft; Azobenzene; Photoisomerization; Molecular packing;

D O I：

10.1007/s00396-008-1936-5

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An azobenzene-modified cholesterol was designed and synthesized for photo-induced domain transformation in lipid bilayer membranes. Upon UV-light irradiation, the cholesterol derivative changes the conformation through photoisomerization of the azobenzene moiety from trans- to cis-form. The photoisomerization effectively occurred both in liquid-ordered (L-o) and liquid-disordered (L-d) phases. Phase-contrast and fluorescence microscopic observation revealed that photoisomerization of the azobenzene-modified cholesterol induced the shape transformation of giant unilamellar vesicle (GUV) and the reorganization of L-o domain structure. Such a photo-induced transformation of lipid domain gave two different pathways dependent on the lipid composition of GUV; disappearance of the L-o domain or appearance of a small L-d domain with in the L-o domain.

引用

页码：1675 / 1680

页数：6

共 29 条

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