"On Water" Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones

被引：1

作者：

Luo, Liang ^{[1
]}

Cao, Xiaomei ^{[1
]}

Lai, Guowei ^{[1
]}

Liu, Jinxiang ^{[1
]}

Luo, Haiqing ^{[1
]}

Lu, Dongliang ^{[1
]}

Zhang, Yong ^{[1
]}

机构：

[1] Gannan Normal Univ, Key Lab Organopharmaceut Chem, Ganzhou 341000, Jiangxi, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 40卷 / 05期

基金：

中国国家自然科学基金;

关键词：

on water" reaction; nucleophilic addition; pyrazolone; trifluoromethyl ketone; ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS; ORGANIC-REACTIONS; CATALYST-FREE; DIFLUOROMETHYLATED ARENES; MICHAEL ADDITION; FACILE SYNTHESIS; ALDOL REACTION; ON-WATER; FLUORINE; CONSTRUCTION;

D O I：

10.6023/cjoc201910038

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green and efficient nucleophilic addition reaction of trifluoromethyl ketone with pyrazolone was developed under "on water" conditions, affording pyrazolone substituted tertiary trifluoromethyl alcohols in high yields. The advantages of being catalyst-free, column chromatography-free, environmentally benign and easy workup make it a promising method for preparation of a variety of pyrazolone substituted tertiary trifluoromethyl alcohols.

引用

页码：1323 / 1330

页数：8

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