Development of a tailor-made bis(oxazolidine)pyridine-metal catalyst for the [3+2] cycloaddition of azomethine imines with propiolates

被引：56

作者：

Arai, Takayoshi ^{[1
]}

Ogino, Yuta ^{[1
]}

Sato, Toru ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Sci, Dept Chem, Chiba 2638522, Japan

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 71期

关键词：

ENANTIOSELECTIVE 1,3-DIPOLAR CYCLOADDITION; ALKYNYLATION; IMINOESTERS; COMPLEXES; LIGANDS; LIBRARY; EXO;

D O I：

10.1039/c3cc44354j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of bis(oxazolidine)pyridine ligands (the PyBodines) were newly designed and synthesized for the development of a highly efficient, tailor-made catalyst for the [3+2] cycloaddition of azomethine imines with propiolates. The PyBodine(L-Ala)-Cu(OAc)(2) catalyst was selected on the basis of solid-phase catalysis/CD-HTS and exhibited high efficiency, producing the (R)-adducts with excellent enantioselectivity.

引用

收藏

页码：7776 / 7778

页数：3

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