Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones

被引：53

作者：

Hosseini, M

Kringelum, H

Murray, A

Tonder, JE

机构：

[1] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark

[2] Novo Nordisk AS, Med Chem Res, DK-2760 Malov, Denmark

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 10期

关键词：

D O I：

10.1021/ol060500i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.

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页码：2103 / 2106

页数：4

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