Could there be Haemodynamic Stress Effects on Pro-Inflammatory CD14+CD16+Monocytes during Convective-Diffusive Treatments? A Prospective Randomized Controlled Trial

被引：7
作者：
Bolasco, Piergiorgio [1 ,2 ]
Spiga, Pierluigi [3 ]
Arras, Marcella [4 ]
Murtas, Stefano [3 ]
La Nasa, Giorgio [4 ]
机构：
[1] ASL 8 Cagliari, Terr Dept Nephrol & Dialysis, Cagliari, Italy
[2] Italian Soc Nephrol, Cagliari, Italy
[3] Dept Nephrol & Dialysis, Cagliari, Italy
[4] Univ Cagliari, Dept Med Sci & Publ Hlth, Businco Hosp, Haematol Unit,Bone Marrow Transplant Ctr, Cagliari, Italy
来源：
BLOOD PURIFICATION | 2019年 / 47卷 / 04期
关键词：
Monocytes CD14+CD16+; Mixed hemodiafiltration; Hemodialysis; DILUTION ONLINE HEMODIAFILTRATION; MIXED-DILUTION; DENDRITIC CELLS; HEMODIALYSIS-PATIENTS; CARDIOVASCULAR RISK; MONOCYTES; BLOOD; MICROINFLAMMATION; SENESCENCE; HDF;
D O I：
10.1159/000494711
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The main aim is to compare the pro-inflammatory CD14+CD16+ monocytes blood levels in patient in end-stage renal disease (ESRD) undergoing Mixed online Haemodiafiltration (Mixed OL-HDF) vs. post-dilution OL-HDF and online high-efficiency haemodialysis. Methods: The study is a prospective double-blind randomized controlled crossover trial. Dialysis monitor, membrane, duration and dialytic adequacy, volume ultrapure dialysate/infusion were the same in all treatments. Monocyte CD14+CD16+, CD14-CD16+, IL-2R, TNF alpha, IL-1 beta, IL-8, IL-6, IL-10, beta 2-microglobulin outcome were measured. Results: Mixed OL-HDF showed a less expression on the activated monocytes CD14+CD16+, CD14-CD16+ (-15.5%). There was no difference between cytokines and high sensitivity C-reactive protein and in other haemato-chemical inflammatory parameters except a significative decrease of TNF-alpha during Mixed OL-HDF. Conclusion: We found that Mixed OL-HDF could inhibit the CD14+CD16+ peripheral blood lymphocytes related to a less hemorheology stress inside capillary dialysis filter but in this study there is not still ascertainable its superiority compared to post OL-HDF and post OL-HEH. (c) 2019 S. Karger AG, Basel
引用
收藏
页码：385 / 394
页数：10
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