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Parkinson's - Divergent causes, convergent mechanisms
被引:349
作者
:
Greenamyre, JT
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Greenamyre, JT
[
1
]
Hastings, TG
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Hastings, TG
机构
:
[1]
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
[2]
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA
来源
:
SCIENCE
|
2004年
/ 304卷
/ 5674期
关键词
:
D O I
:
10.1126/science.1098966
中图分类号
:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号
:
07 ;
0710 ;
09 ;
摘要
:
[No abstract available]
引用
收藏
页码:1120 / 1122
页数:3
相关论文
共 21 条
[1]
Commentary on "Alpha-synuclein and mitochondria: a tangled skein"
[J].
Beal, MF
论文数:
0
引用数:
0
h-index:
0
机构:
Cornell Univ, Weill Med Coll, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, New York, NY 10021 USA
Beal, MF
.
EXPERIMENTAL NEUROLOGY,
2004,
186
(02)
:109
-111
[2]
Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: Implications for Parkinson's disease
[J].
Berman, SB
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15261 USA
Berman, SB
;
Hastings, TG
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15261 USA
Hastings, TG
.
JOURNAL OF NEUROCHEMISTRY,
1999,
73
(03)
:1127
-1137
[3]
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
[J].
Betarbet, R
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Betarbet, R
;
Sherer, TB
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Sherer, TB
;
MacKenzie, G
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
MacKenzie, G
;
Garcia-Osuna, M
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Garcia-Osuna, M
;
Panov, AV
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Panov, AV
;
Greenamyre, JT
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Greenamyre, JT
.
NATURE NEUROSCIENCE,
2000,
3
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:1301
-1306
[4]
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
[J].
Bonifati, V
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Bonifati, V
;
Rizzu, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Rizzu, P
;
van Baren, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Baren, MJ
;
Schaap, O
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Schaap, O
;
Breedveld, GJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Breedveld, GJ
;
Krieger, E
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Krieger, E
;
Dekker, MCJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Dekker, MCJ
;
Squitieri, F
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Squitieri, F
;
Ibanez, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Ibanez, P
;
Joosse, M
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Joosse, M
;
van Dongen, JW
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Dongen, JW
;
Vanacore, N
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Vanacore, N
;
van Swieten, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Swieten, JC
;
Brice, A
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Brice, A
;
Meco, G
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Meco, G
;
van Duijn, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Duijn, CM
;
Oostra, BA
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Oostra, BA
;
Heutink, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Heutink, P
.
SCIENCE,
2003,
299
(5604)
:256
-259
[5]
CHEN R, 2004, J BIOL CHEM
[6]
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
[J].
Conway, KA
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Conway, KA
;
Rochet, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Rochet, JC
;
Bieganski, RM
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Bieganski, RM
;
Lansbury, PT
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Lansbury, PT
.
SCIENCE,
2001,
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:1346
-1349
[7]
Molecular pathways of neurodegeneration in Parkinson's disease
[J].
Dawson, TM
论文数:
0
引用数:
0
h-index:
0
机构:
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Dawson, TM
;
Dawson, VL
论文数:
0
引用数:
0
h-index:
0
机构:
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Dawson, VL
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SCIENCE,
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Oxidative stress in Parkinson's disease
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Kings Coll London, GKT Sch Biomed Sci, NDRC, London SE1 1UL, England
Kings Coll London, GKT Sch Biomed Sci, NDRC, London SE1 1UL, England
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Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Kitada, T
;
Asakawa, S
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机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Asakawa, S
;
Hattori, N
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机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Hattori, N
;
Matsumine, H
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机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Matsumine, H
;
Yamamura, Y
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0
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0
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机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Yamamura, Y
;
Minoshima, S
论文数:
0
引用数:
0
h-index:
0
机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Minoshima, S
;
Yokochi, M
论文数:
0
引用数:
0
h-index:
0
机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Yokochi, M
;
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引用数:
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机构:
Mizuno, Y
;
Shimizu, N
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Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
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0
引用数:
0
h-index:
0
机构:
SANTA CLARA VALLEY MED CTR,SAN JOSE,CA 95128
LANGSTON, JW
;
论文数:
引用数:
h-index:
机构:
BALLARD, P
;
TETRUD, JW
论文数:
0
引用数:
0
h-index:
0
机构:
SANTA CLARA VALLEY MED CTR,SAN JOSE,CA 95128
TETRUD, JW
;
IRWIN, I
论文数:
0
引用数:
0
h-index:
0
机构:
SANTA CLARA VALLEY MED CTR,SAN JOSE,CA 95128
IRWIN, I
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SCIENCE,
1983,
219
(4587)
:979
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←
1
2
3
→
共 21 条
[1]
Commentary on "Alpha-synuclein and mitochondria: a tangled skein"
[J].
Beal, MF
论文数:
0
引用数:
0
h-index:
0
机构:
Cornell Univ, Weill Med Coll, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, New York, NY 10021 USA
Beal, MF
.
EXPERIMENTAL NEUROLOGY,
2004,
186
(02)
:109
-111
[2]
Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: Implications for Parkinson's disease
[J].
Berman, SB
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15261 USA
Berman, SB
;
Hastings, TG
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15261 USA
Hastings, TG
.
JOURNAL OF NEUROCHEMISTRY,
1999,
73
(03)
:1127
-1137
[3]
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
[J].
Betarbet, R
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Betarbet, R
;
Sherer, TB
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Sherer, TB
;
MacKenzie, G
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
MacKenzie, G
;
Garcia-Osuna, M
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Garcia-Osuna, M
;
Panov, AV
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Panov, AV
;
Greenamyre, JT
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Greenamyre, JT
.
NATURE NEUROSCIENCE,
2000,
3
(12)
:1301
-1306
[4]
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
[J].
Bonifati, V
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Bonifati, V
;
Rizzu, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Rizzu, P
;
van Baren, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Baren, MJ
;
Schaap, O
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Schaap, O
;
Breedveld, GJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Breedveld, GJ
;
Krieger, E
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Krieger, E
;
Dekker, MCJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Dekker, MCJ
;
Squitieri, F
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Squitieri, F
;
Ibanez, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Ibanez, P
;
Joosse, M
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Joosse, M
;
van Dongen, JW
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Dongen, JW
;
Vanacore, N
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Vanacore, N
;
van Swieten, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Swieten, JC
;
Brice, A
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Brice, A
;
Meco, G
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Meco, G
;
van Duijn, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Duijn, CM
;
Oostra, BA
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Oostra, BA
;
Heutink, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Heutink, P
.
SCIENCE,
2003,
299
(5604)
:256
-259
[5]
CHEN R, 2004, J BIOL CHEM
[6]
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
[J].
Conway, KA
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Conway, KA
;
Rochet, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Rochet, JC
;
Bieganski, RM
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Bieganski, RM
;
Lansbury, PT
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Lansbury, PT
.
SCIENCE,
2001,
294
(5545)
:1346
-1349
[7]
Molecular pathways of neurodegeneration in Parkinson's disease
[J].
Dawson, TM
论文数:
0
引用数:
0
h-index:
0
机构:
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Dawson, TM
;
Dawson, VL
论文数:
0
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