Association of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree

被引：25

作者：

Rodriguez-Acevedo, Astrid J. ^{[1
]}

Maher, Bridget H. ^{[1
]}

Lea, Rodney A. ^{[1
]}

Benton, Miles ^{[1
]}

Griffiths, Lyn R. ^{[1
]}

机构：

[1] Griffith Univ, Griffith Hlth Inst, Genom Res Ctr, Nathan, Qld 4222, Australia

来源：

CEPHALALGIA | 2013年 / 33卷 / 14期

基金：

英国医学研究理事会;

关键词：

Migraine; hormone receptor genes; ESR1; PGR; haplotype analysis; UNDERSTANDING MECHANISMS; OVARIAN HORMONES; GENOME; PATHOGENESIS; HEADACHE;

D O I：

10.1177/0333102413486321

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Oestrogen receptor 1 (ESR1) is located in region 6q25.1 and encodes a ligand-activated transcription factor composed of several domains important for hormone binding and transcription activation. Progesterone receptor (PGR) is located in 11q22-23 and mediates the role of progesterone interacting with different transcriptional co-regulators. ESR1 and PGR have previously been implicated in migraine susceptibility. Here, we report the results of an association study of these genes in a migraine pedigree from the genetic isolate of Norfolk Island, a population descended from a small number of Isle of Man Bounty Mutineer and Tahitian founders. Methods A significant number of molecular markers in the ESR1 (143) and PGR (43) genes were evaluated in a sample of 285 related individuals (135 males; 150 females). A pedigree-based analysis in the GenABEL package was used to analyse the results. Results and conclusions A total of 10 markers in the ESR1 gene showed association with migraine (p<0.05) in the Norfolk Island population. No association was detected with PGR. Three haplotypes in ESR1 were found to be associated with migraine (p=0.004, 0.03, 0.005). Future genetic studies in larger populations and expression analysis are required to clarify the role of ESR1 in migraine susceptibility.

引用

页码：1139 / 1147

页数：9

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