An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools

被引：82

作者：

Gong, Jing ^{[1
,2
]}

Liu, Chunjie ^{[1
]}

Liu, Wei ^{[1
]}

Wu, Yuliang ^{[1
]}

Ma, Zhaowu ^{[1
]}

Chen, Hu ^{[1
]}

Guo, An-Yuan ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Biomed Engn, Wuhan 430074, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430074, Hubei, Peoples R China

来源：

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2015年

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

MICRORNA TARGET SITES; HUMAN-DISEASES; LINKING POLYMORPHISMS; RESOURCE; PROFILES; LOCI;

D O I：

10.1093/database/bav029

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs (miRNAs) are key regulators of gene expression involved in a broad range of biological processes. MiRNASNP aims to provide single nucleotide polymorphisms (SNPs) in miRNAs and genes that may impact miRNA biogenesis and/or miRNA target binding. Advanced miRNA research provided abundant data about miRNA expression, validated targets and related phenotypic variants. In miRNASNP v2.0, we have updated our previous database with several new data and features, including: (i) expression level and expression correlation of miRNAs and target genes in different tissues, (ii) linking SNPs to the results of genome-wide association studies, (iii) integrating experimentally validated miRNA: mRNA interactions, (iv) adding multiple filters to prioritize functional SNPs. In addition, as a supplement of the database, we have set up three flexible online tools to analyse the influence of novel variants on miRNA: mRNA binding. A new nice web interface was designed for miRNASNP v2.0 allowing users to browse, search and download. We aim to maintain the miRNASNP as a solid resource for function, genetics and disease studies of miRNA-related SNPs. Database URL: http://bioinfo.life.hust.edu.cn/miRNASNP2/.

引用

页数：8

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