Synthesis and Structure of Methyl 6-Aryl-5-aroyl-4-hydroxy2-oxo(thioxo)hexahydropyrimidine-4-carboxylates

被引：0
作者：
Gein, V. L. [1 ]
Zamaraeva, T. M. [1 ]
Gorgopina, E. V. [1 ]
Dmitriev, M. V. [2 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
[2] Perm State Natl Res Univ, Perm 614990, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2022年 / 92卷 / 10期
关键词：
Biginelli reaction; aroylpyruvic acids methyl esters; arylaldehydes; urea; thiourea; 4-hydroxy-2oxo(thioxo)pyrimidine; BIGINELLI REACTION; 1,3-DICARBONYL COMPOUNDS; DERIVATIVES; EFFICIENT;
D O I：
10.1134/S1070363222100036
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction of aroylpyruvic acids methyl esters with aromatic aldehyde and urea (thiourea) in methanol leads to the formation of methyl 6-aryl-5-aroyl-4-hydroxy-2-oxo(thioxo)hexahydropyrimidine-4-carboxylates. Structure of the obtained compounds was established by H-1, C-13 NMR spectroscopy and single crystal X-ray diffraction analysis.
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页码：1894 / 1898
页数：5
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