Significance of serum-soluble CD95 (Fas/APO-1) on prognosis in renal cell cancer patients

被引：22

作者：

Kimura, M ^{[1
]}

Tomita, Y ^{[1
]}

Imai, T ^{[1
]}

Saito, T ^{[1
]}

Katagiri, A ^{[1
]}

Tanikawa, T ^{[1
]}

Takeda, M ^{[1
]}

Takahashi, K ^{[1
]}

机构：

[1] Niigata Univ, Sch Med, Dept Urol, Niigata 9518510, Japan

来源：

BRITISH JOURNAL OF CANCER | 1999年 / 80卷 / 10期

关键词：

soluble CD95 (Fas/APO-1); renal cell cancer; prognosis;

D O I：

10.1038/sj.bjc.6690576

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Serum-soluble CD95 (sCD95) levels for 72 renal cell cancer patients were significantly higher than those of 17 healthy donors. Twenty-one of 72 patients had elevated (defined as more than mean of healthy donors + 2 s.d.) sCD95. The disease-specific survival rate was significantly lower in the elevated sCD95 group. Serum sCD95 level was shown to be an independent prognostic factor by univariate and multivariate analysis, indicating a possible significant role in determining treatment strategies.

引用

页码：1648 / 1651

页数：4

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