Therapeutic approaches to Epstein-Barr virus cancers

被引：12
作者：
Soldan, Samantha S. [1 ]
Messick, Troy E. [1 ]
Lieberman, Paul M. [1 ]
机构：
[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
来源：
CURRENT OPINION IN VIROLOGY | 2022年 / 56卷
关键词：
ORIGIN-BINDING PROTEIN; T-CELLS; LYTIC CYCLE; NASOPHARYNGEAL CARCINOMA; ADOPTIVE IMMUNOTHERAPY; VACCINE DEVELOPMENT; CRYSTAL-STRUCTURE; IMMUNE-RESPONSE; SMALL MOLECULES; DNA VACCINE;
D O I：
10.1016/j.coviro.2022.101260
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Epstein–Barr virus (EBV) establishes a lifelong latent infection that can be a causal agent for a diverse spectrum of cancers and autoimmune disease. A complex and dynamic viral lifecycle evades eradication by the host immune system and confounds antiviral therapeutic strategies. To date, there are no clinically approved vaccines or therapies that selectively target EBV as the underlying cause of EBV-associated disease. Here, we review the challenges and recent advances in the development of EBV-specific therapeutics for treatment of EBV-associated cancers. © 2022 Elsevier B.V.
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页数：10
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