Asymmetric Michael Additions of α-Nitrocyclohexanone to Aryl Nitroalkenes Catalyzed by Natural Amino Acid-Derived Bifunctional Thioureas

被引：37

作者：

Joerres, Manuel ^{[1
]}

Schiffers, Ingo ^{[1
]}

Atodiresei, Iuliana ^{[1
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 17期

关键词：

HYDROGEN-BONDING DONORS; ENANTIOSELECTIVE MICHAEL; QUATERNARY STEREOCENTERS; CONJUGATE ADDITIONS; ORGANOCATALYSTS; ACTIVATION; NITROOLEFINS; CONSTRUCTION; SEQUENCE; NITRO;

D O I：

10.1021/ol302005f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new thiourea catalysts prepared from natural amino acids have been applied in organocatalytic asymmetric Michael additions of alpha-nitrocyclohexanone to nitroalkenes. The resulting addition products are formed with excellent enantioselectivities (up to an er of 98:2) in good yields (up to 90%).

引用

页码：4518 / 4521

页数：4

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