Construction of benzo-fused indolizines, pyrrolo[1,2-a]quinolines via alkyne-carbonyl metathesis

被引：40

作者：

Nayak, Maloy

Kim, Ikyon ^{[1
]}

机构：

[1] Yonsei Univ, Coll Pharm, Inchon 406840, South Korea

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 37期

基金：

新加坡国家研究基金会;

关键词：

ONE-POT APPROACH; C-H ACTIVATION; CYCLIC ENONES; INTRAMOLECULAR CARBOCYCLIZATION; CATALYZED SYNTHESIS; COUPLING REACTION; ALDEHYDES; DERIVATIVES; CYCLIZATION; INHIBITORS;

D O I：

10.1039/c5ob01383f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The strategic use of a sequential Sonogashira coupling/intramolecular alkyne-carbonyl metathesis process for the synthesis of a pyridine ring from 1-(2-haloaryl)-1H-pyrrole-2-carbaldehydes allowed ready access to diverse novel benzo-fused indolizines, pyrrolo[1,2-a]quinolines, in good to excellent yields. As a hybrid structure of indolizine and quinoline, the resulting scaffold has an acyl substituent at the C5 position, which is difficult to make by any other known approaches.

引用

页码：9697 / 9708

页数：12

共 54 条

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