Fabrication of Fe3O4/O-Carboxylmethyl Chitosan Magnetic Particle Assembles in Inverse Miniemulsions for Loading and Release of Bovine Serum Albumin

被引：3
作者：
Gao, Feng [1 ,2 ]
Qi, Qi [1 ,2 ]
Liang, Xiaoqin [1 ,2 ]
Wen, Lixin [1 ,2 ]
Shang, Yi [1 ,2 ]
Mi, Yifang [1 ,2 ]
Ziener, Ulrich [3 ]
Cao, Zhihai [1 ,2 ]
机构：
[1] Zhejiang Sci Tech Univ, Minist Educ, Key Lab Adv Text Mat & Mfg Technol, Hangzhou 310018, Peoples R China
[2] Zhejiang Sci Tech Univ, Minist Educ, Engn Res Ctr Ecodyeing & Finishing Text, Hangzhou 310018, Peoples R China
[3] Univ Ulm, Inst Organ Chem Macromol Chem & Organ Mat 3, Albert Einstein Allee 11, D-89081 Ulm, Germany
来源：
CHEMISTRYSELECT | 2020年 / 5卷 / 27期
基金：
中国国家自然科学基金;
关键词：
Hydrogen bond; Inverse miniemulsion; Magnetic property; protein delivery; Schiff base reaction; IRON-OXIDE NANOPARTICLES; CARBOXYMETHYL CHITOSAN; MICROSPHERE; REMOVAL; POLYMERIZATION; POLYACRYLAMIDE; COMBINATION; CLUSTERS;
D O I：
10.1002/slct.202001784
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fe3O4/O-carboxylmethyl chitosan (OCMC) magnetic particle assembles (MPAs) with high magnetite loading and superparamagnetism were controllably prepared through Schiff base crosslinking reaction of OCMC-stabilized Fe(3)O(4)magnetic nanoparticles (OCMC-Fe(3)O(4)MNPs) in the dispersed phase of inverse miniemulsions. The Fe3O4/OCMC MPAs were composed of many tiny Fe(3)O(4)MNPs, and they did not only inherit the good superparamagnetism of OCMC-Fe(3)O(4)MNPs, but also displayed high collective magnetic response to an external magnetic field. The crosslinked network of OCMC offered a good structural integrity of the Fe3O4/OCMC MPAs either in inverse emulsions or in aqueous dispersions within a wide pH range. The Fe3O4/OCMC MPAs displayed a reversible pH-dependent loading and release behavior of a model protein, bovine serum albumin, exhibiting a great potential in functioning as nanocarriers for loading and release of biomacromolecules.
引用
收藏
页码：8344 / 8351
页数：8
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