Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan

被引：359
作者：
Lin, Jack J. [2 ]
Mula, Marco [3 ]
Hermann, Bruce P. [1 ]
机构：
[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Neurol, Madison, WI 53705 USA
[2] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA
[3] Amedeo Avogadro Univ, Dept Neurol, Novara, Italy
来源：
LANCET | 2012年 / 380卷 / 9848期
基金：
美国国家卫生研究院;
关键词：
TEMPORAL-LOBE EPILEPSY; SEIZURE-RELATED FACTORS; BENIGN CHILDHOOD EPILEPSY; QUALITY-OF-LIFE; PSYCHIATRIC COMORBIDITY; PRESCHOOL-CHILDREN; MAJOR DEPRESSION; RISK-FACTOR; EXECUTIVE DYSFUNCTION; COGNITIVE IMPAIRMENT;
D O I：
10.1016/S0140-6736(12)61455-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Epilepsy is a common neurological disorder that is complicated by psychiatric, cognitive, and social comorbidities that have become a major target of concern and investigation in view of their adverse effect on the course and quality of life. In this report we define the specific psychiatric, cognitive, and social comorbidities of paediatric and adult epilepsy, their epidemiology, and real life effects; examine the relation between epilepsy syndromes and the risk of neurobehavioural comorbidities; address the lifespan effect of epilepsy on brain neurodevelopment and brain ageing and the risk of neurobehavioural comorbidities; consider the overarching effect of broader brain disorders on both epilepsy and neurobehavioural comorbidities; examine directions of causality and the contribution of selected epilepsy-related characteristics; and outline clinic-friendly screening approaches for these problems and recommended pharmacological, behavioural, and educational interventions.
引用
收藏
页码：1180 / 1192
页数：13
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