Stereoselective Cascade Double-Annulations Provide Diversely Ring-Fused Tetracyclic Benzopyrones

被引：28

作者：

Baskar, Baburaj ^{[1
]}

Wittstein, Kathrin ^{[1
,2
]}

Sankar, Muthukumar G. ^{[1
]}

Khedkar, Vivek ^{[1
]}

Schuermann, Markus ^{[2
]}

Kumar, Kamal ^{[1
,2
]}

机构：

[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany

[2] Tech Univ Dortmund, Fak Chem, D-44221 Dortmund, Germany

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 23期

关键词：

BOND-FORMING REACTIONS; SYNTHETIC STRATEGY; BRONSTED ACID; EFFICIENT SYNTHESIS; ORIENTED SYNTHESIS; ORGANIC-SYNTHESIS; DUAL CATALYSIS; AZODICARBOXYLATE; DERIVATIVES; MOLECULES;

D O I：

10.1021/ol3028412

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cascade double-annulation strategy employing diverse pairs of zwitterions with 3-formylchromones is presented that provides stereoselective access to complex tetracyclic benzopyrones. Different zwitterions incorporated different rings that include aza-, oxa-, and carbocycles fused to a common benzopyrone scaffold and in the process created three contiguous chiral centers including an all-carbon-quaternary center with high efficiency and excellent stereoselectivity.

引用

页码：5924 / 5927

页数：4

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