DNA Interstrand Cross-Linking Agents and their Chemotherapeutic Potential

被引：46
作者：
Brulikova, L. [1 ]
Hlavac, J. [1 ]
Hradil, P. [1 ]
机构：
[1] Palacky Univ, Fac Sci, Inst Mol & Translat Med, Dept Organ Chem, Olomouc 77146, Czech Republic
来源：
CURRENT MEDICINAL CHEMISTRY | 2012年 / 19卷 / 03期
关键词：
Chemotherapy; cytotoxicity; DNA; interstrand cross-link; ICL; repair; resistance; NUCLEOTIDE EXCISION-REPAIR; FANCONI-ANEMIA PATHWAY; GROUP DOMAIN PROTEINS; MINOR-GROOVE; ANTITUMOR-ACTIVITY; CANCER CELLS; IN-VITRO; ATAXIA-TELANGIECTASIA; REDUCTIVE ACTIVATION; SELECTIVE INHIBITOR;
D O I：
10.2174/092986712803414295
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA interstrand cross-linking (ICL) agents are an important group of cytotoxic drugs with the capability of binding covalently between two strands of DNA, thereby preventing vital processes such as replication or transcription in dividing cells. In anticancer therapy however, their potential is limited due to the resistance by various mechanisms. In order to develop highly effective antitumor drugs it is necessary to study both effective ICL formations and their subsequent repair mechanisms. This review presents an overview of development over the past decade and the use of both well-known and new DNA interstrand cross-linking agents. Their potential in applications especially as anticancer chemotherapeutics in the framework of current knowledge of repair mechanisms and development of combined chemotherapy is discussed.
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页码：364 / 385
页数：22
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