New tracers developed in positron emission tomography: A possible second breath in targeting tumour hypoxia?

被引：5

作者：

Baillet, G. ^{[1
]}

Groheux, D. ^{[1
]}

Barre, E. ^{[1
]}

Toubert, M. -E. ^{[1
]}

Dechaud, C. ^{[1
]}

Teyton, P. ^{[1
]}

de Hemricourt, E. Le Beau ^{[2
]}

Moretti, J. -L. ^{[1
]}

机构：

[1] Hop St Louis, Nucl Med Serv, F-75475 Paris 10, France

[2] Ctr Imagerie Nucl Dunkerque, F-59240 Dunkerque, France

来源：

MEDECINE NUCLEAIRE-IMAGERIE FONCTIONNELLE ET METABOLIQUE | 2008年 / 32卷 / 12期

关键词：

PET imaging; Hypoxia; FAZA; Cu-ATSM;

D O I：

10.1016/j.mednuc.2008.07.009

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

There is an increasing interest for targeting of tumor hypoxia and our paper aimed to emphasize the main points of this topic. We review new insights at cellular level and focus on the leading part of hypoxia inducible factor one alpha and its connections with angiogenesis. We shortly describe different methods to assess tissue hypoxia then zoom on to positron emission tomography and its acknowledged tracers F-18-fluoromisonidazole and F-18-fluoroerythronitroimidazole. Recent studies concerning two new promising tracers Cu(II)-diacetyl-bis(N(4)-methylthiosemicarbazone) and FAZA are reviewed, and the respective value of the tracers is discussed. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：607 / 613

页数：7

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