Iodine-Mediated Three-Component Strategy to Synthesize 2-Aminothiazoles from β-Diketones/β-ketoesters, Arylamines and Ammonium Thiocyanate

被引：6

作者：

Philips, Abigail ^{[1
]}

Arumugam, Ajithkumar ^{[1
]}

Eswaramoorthy, Yuvaprabhu ^{[2
]}

Boominathan, Siva Senthil Kumar ^{[2
]}

Senadi, Gopal Chandru ^{[1
]}

机构：

[1] SRM Inst Sci & Technol, Dept Chem, Kattankulathur 603203, India

[2] Sri Ramakrishna Mission Vidyalaya Coll Arts & Sci, Dept Chem, Coimbatore 641020, Tamilnadu, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 2022卷 / 46期

关键词：

Aminothiazoles; 1; 3-Dicarbonyls; Multicomponent reaction; Metal-Free; Thiocyanate; IN-VITRO; BIOLOGICAL EVALUATION; DERIVATIVES; DISCOVERY; POTENT; CHEMISTRY; MELOXICAM; DESIGN;

D O I：

10.1002/ejoc.202201233

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot, three-component protocol for the synthesis of 2-aminothiazoles promoted by iodine from readily available starting materials such as beta-diketones/beta-ketoesters, arylamines, and NH4SCN has been developed. A wide range of arylamines was tolerated well to produce the expected polysubstituted 2-aminothiazoles in moderate to good yields. The characteristic features of this methodology include operational ease, metal-free reaction conditions, gram-scale scalability, functional group tolerance, and short reaction times.

引用

页数：6

共 9 条

[1] One-Pot Three-Component Strategy for Polysubstituted 2-Aminothiazoles via Ring Opening of -Nitro Epoxides
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[3] Iodine-mediated construction of polyfunctionalized arylazopyrazoles from β-ketoesters or 2-arylpyrazol-3-ones and arylhydrazines
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