Cardiac contractility after transplantation of autologous mononuclear bone marrow cells in patients with myocardial infarction

被引：8
|
作者：
Ryabov, V. V. [1 ]
Krylov, A. L. [1 ]
Poponina, Yu. S. [1 ]
Maslov, L. N. [1 ]
机构：
[1] Russian Acad Med Sci, Siberian Div, Tomsk Res Ctr, Inst Cardiol, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
rnyocardial infarction; transplantation; bone marrow mononuclear cells; cardiac contractility;
D O I：
10.1007/s10517-006-0111-6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Autologous bone marrow mononuclear cells were transplanted by intracoronary infusion to patients with myocardial infarction after recovery of coronary perfusion. Controls received traditional therapy alone. Echocardiography was carried out before and 3 and 6 months after cell therapy. Cell transplantation did not appreciably improved left-ventricular contractility in comparison with the control group. In none patient cell therapy provoked malignant ventricular arrhythmias. Intracoronary infusion of bone marrow mononuclear cells in patients with myocardial infarction did not improve cardiac contractility and did not aggravate the course of the disease.
引用
收藏
页码：124 / 128
页数：5
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