Crosstalk between prognostic long noncoding RNAs and messenger RNAs as transcriptional hallmarks in gastric cancer

被引：9
作者：
Zhang, Jian [1 ,2 ]
Yuan, Yujie [1 ,2 ]
Wei, Zhewei [1 ,2 ]
Ren, Jianwei [3 ,4 ]
Hou, Xun [1 ,2 ]
Yang, Dongjie [1 ,2 ]
Cai, Sirong [1 ,2 ]
Chen, Chuangqi [1 ,2 ]
Tan, Min [1 ,2 ]
Chen, George Gong [3 ,4 ]
Wu, Kaiming [1 ,2 ]
He, Yulong [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Div Gastrointestinal Surg, Guangzhou, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Gastr Canc Ctr, Guangzhou, Guangdong, Peoples R China
[3] Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China
[4] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China
来源：
EPIGENOMICS | 2018年 / 10卷 / 04期
基金：
中国国家自然科学基金;
关键词：
long noncoding RNA; messenger RNA; stomach neoplasms; CELL-PROLIFERATION; GENE; EXPRESSION; CARCINOMA; ADENOCARCINOMA; IDENTIFICATION; METASTASIS; REGULATOR; BIOMARKER; BINDING;
D O I：
10.2217/epi-2017-0136
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: Our study investigated the significance of the crosstalk between long noncoding RNAs (lncRNAs) and mRNAs in gastric cancer (GC). Methods: lncRNA and mRNA expression profiling data in 671 GC tumors and 77 nontumorous gastric tissues were retrieved from the gene expression omnibus database: GSE54129, GSE13911, GSE19826, GSE79973, GSE15459 and GSE66229. Differentially expressed analysis, RNA coexpression network construction, gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses were conducted in this study. Results: Using differentially expressed and prognostic lncRNAs or mRNAs in GC, we constructed the lncRNA-mRNA coexpression networks. This network involved with vital GO and KEGG pathways. Conclusion: Our study reveals coexpressed lncRNAs and mRNAs as transcriptional hallmarks in GC patients which provide interesting information regarding the incidence and outcome of GC.
引用
收藏
页码：433 / 443
页数：11
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