Microparticles of Diethylcarbamazine Citrate for the Treatment of Lymphatic Filariasis

被引:0
作者
Shukla, Rahul [1 ]
Kumar, J. [1 ]
Dwivedi, P. [1 ]
Gatla, P. [1 ]
Mishra, P. R. [1 ]
机构
[1] Cent Drug Res Inst, Div Pharmaceut, Lucknow 226001, Uttar Pradesh, India
关键词
Diethlcarbamazine citrate; Microparicles; Lymphatic filariasis; IN-VITRO; DELIVERY; NANOPARTICLES; VIVO;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The aim of the study is to study the fabrication of microparticles for antifilarial drug diethylcarbamazine citrate with increased efficacy, decrease dose and minimise its side effects. Lymphatic filariasis is one of the major causes of chronic disability in the developing countries and, as such, produces a considerable economic burden. The microparticles were prepared by two steps, using alginates by spray drying step and crosslinking step. Entrapment efficiency, in vitro drug release study was performed of the developed formulations. FT-IR and mass spectrophotometry were performed of the formulations. Diethylcarbamazine citrate is drug used in the management of lymphatic filariasis in both early and advanced stages. In the development of alginate/chitosan microparticles for the diethylcarbamazine citrate delivery to lymphatic system, the preformulations studies were performed. Microparticles polymer network and, consequently, drug loading level and release, were affected by the alginate and crosslinking agent concentrations. Results were favourable for our novel drug delivery system developed for neglected tropical disease such as filariasis.
引用
收藏
页码:S302 / S304
页数:3
相关论文
共 11 条
[1]   Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds [J].
Anumolu, SivaNaga S. ;
DeSantis, Andrea S. ;
Menjoge, Anupa R. ;
Hahn, Rita A. ;
Beloni, John A. ;
Gordon, Marion K. ;
Sinko, Patrick J. .
BIOMATERIALS, 2010, 31 (05) :964-974
[2]   Alginate/chitosan microparticles for tamoxifen delivery to the lymphatic system [J].
Coppi, G. ;
Iannuccelli, V. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 367 (1-2) :127-132
[3]   Improvement in the antifilarial efficacy of doxycycline and rifampicin by combination therapy and drug delivery approach [J].
Dangi, Anil ;
Dwivedi, Varun ;
Vedi, Satish ;
Owais, Mohammad ;
Misra-Bhattacharya, Shailja .
JOURNAL OF DRUG TARGETING, 2010, 18 (05) :343-350
[4]   Exploiting 4-sulphate N-acetyl galactosamine decorated gelatin nanoparticles for effective targeting to professional phagocytes in vitro and in vivo [J].
Dwivedi, Pankaj ;
Kansal, Shaswat ;
Sharma, Monika ;
Shukla, Rahul ;
Verma, Ashwini ;
Shukla, Prashant ;
Tripathi, Priyanka ;
Gupta, Pramod ;
Saini, Deepika ;
Khandelwal, Kiran ;
Verma, Rahul ;
Dwivedi, Anil Kumar ;
Mishra, Prabhat Ranjan .
JOURNAL OF DRUG TARGETING, 2012, 20 (10) :883-896
[5]   Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics [J].
Hussain, N ;
Jaitley, V ;
Florence, AT .
ADVANCED DRUG DELIVERY REVIEWS, 2001, 50 (1-2) :107-142
[6]   Ciprofloxacin surf-plexes in sub-micron emulsions: A novel approach to improve payload efficiency and antimicrobial efficacy [J].
Jain, Vikas ;
Singodia, Deepak ;
Gupta, Girish K. ;
Garg, Durga ;
Keshava, G. B. Shiva ;
Shukla, Rahul ;
Shukla, Praveen K. ;
Mishra, Prabhat R. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 409 (1-2) :237-244
[7]   Influenza vaccine powder formulation development: Spray-freeze-drying and stability evaluation [J].
Maa, YF ;
Ameri, M ;
Shu, C ;
Payne, LG ;
Chen, DX .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 93 (07) :1912-1923
[8]   Lymphatic filariasis: new insights into an old disease [J].
Melrose, WD .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2002, 32 (08) :947-960
[9]   Development and evaluation of novel biodegradable microspheres based on poly(D,L-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket:: In vitro and in vivo studies [J].
Mundargi, Raghavendra C. ;
Srirangarajan, S. ;
Agnihotri, Sunil A. ;
Patil, Sangamesh A. ;
Ravindra, S. ;
Setty, Swati B. ;
Aminabhavi, Tejraj M. .
JOURNAL OF CONTROLLED RELEASE, 2007, 119 (01) :59-68
[10]   Immunomodulator tuftsin augments antifilarial activity of diethylcarbamazine against experimental brugian filariasis [J].
Owais, M ;
Misra-Bhattacharya, S ;
Haq, W ;
Gupta, CM .
JOURNAL OF DRUG TARGETING, 2003, 11 (04) :247-251