Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning

被引：58

作者：

Baranov, Pavel V. ^{[1
]}

Atkins, John F. ^{[1
,2
]}

Yordanova, Martina M. ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Sch Biochem & Cell Biol, Cork, Ireland

[2] Univ Utah, Dept Human Genet, Salt Lake City, UT 84112 USA

来源：

NATURE REVIEWS GENETICS | 2015年 / 16卷 / 09期

基金：

英国惠康基金;

关键词：

RIBOSOMAL FRAMESHIFT SIGNALS; ORNITHINE-DECARBOXYLASE ANTIZYME; MAMMALIAN THIOREDOXIN REDUCTASE; OPEN READING FRAMES; RNA G-QUADRUPLEX; MESSENGER-RNA; STOP-CODON; SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI; UGA CODONS;

D O I：

10.1038/nrg3963

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The non-universality of the genetic code is now widely appreciated. Codes differ between organisms, and certain genes are known to alter the decoding rules in a site-specific manner. Recently discovered examples of decoding plasticity are particularly spectacular. These examples include organisms and organelles with disruptions of triplet continuity during the translation of many genes, viruses that alter the entire genetic code of their hosts and organisms that adjust their genetic code in response to changing environments. In this Review, we outline various modes of alternative genetic decoding and expand existing terminology to accommodate recently discovered manifestations of this seemingly sophisticated phenomenon.

引用

页码：517 / 529

页数：13

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