Nutrient availability and growth - Regulation of insulin signaling by dFOXO/FOXO1

被引:62
作者
Puig, O
Tjian, R
机构
[1] Univ Helsinki, Inst Biotechnol, FIN-00014 Helsinki, Finland
[2] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA
关键词
FOXO; insulin signaling; insulin receptor; transcription factor; growth; Drosophila melanogaster; nutrients;
D O I
10.4161/cc.5.5.2501
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Organisms adjust their rate of growth depending on the availability of nutrients. Thus, when environmental conditions limit nutrients, growth is slowed and is only restored after food again becomes abundant. Many aspects of the molecular mechanisms that govern this complex control system remain unknown. However, it has been shown that the insulin/IGF-1 (insulin-like growth factor 1) receptor pathway, together with the FOXO family of transcription factors, play an important role in this process. Recent studies with the fruit fly Drosophila melanogaster have provided new insights into the regulatory circuitry that controls both growth and gene expression in response to nutrient availability.
引用
收藏
页码:503 / 505
页数:3
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