Channel-forming toxins: Tales of transformation

被引：141
作者：
Gouaux, E
机构：
[1] Dept. Biochem. and Molec. Biophys., Columbia Univ., 650 W. 168th Street, New York
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 04期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
D O I：
10.1016/S0959-440X(97)80123-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Channel-forming bacterial toxins undergo a series of remarkable changes in solubility, oligomerization state, structure and dynamics during the processes of membrane binding, assembly, membrane insertion and channel formation. Recent high-resolution crystal structures of channel-forming toxins, in both water-soluble and membrane-bound, channel-formed slates, have brought a wealth of new information to bear on issues of structure, mechanism and function.
引用
收藏
页码：566 / 573
页数：8
相关论文
共 63 条
  • [1] THE PRIMARY STRUCTURE OF CLOSTRIDIUM-SEPTICUM ALPHA-TOXIN EXHIBITS SIMILARITY WITH THAT OF AEROMONAS-HYDROPHILA AEROLYSIN
    BALLARD, J
    CRABTREE, J
    ROE, BA
    TWETEN, RK
    [J]. INFECTION AND IMMUNITY, 1995, 63 (01) : 340 - 344
  • [2] COLICIN-A UNFOLDS DURING ITS TRANSLOCATION IN ESCHERICHIA-COLI-CELLS AND SPANS THE WHOLE CELL-ENVELOPE WHEN ITS PORE HAS FORMED
    BENEDETTI, H
    LLOUBES, R
    LAZDUNSKI, C
    LETELLIER, L
    [J]. EMBO JOURNAL, 1992, 11 (02) : 441 - 447
  • [3] Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: Prototypes of pore-forming bacterial cytolysins
    Bhakdi, S
    Bayley, H
    Valeva, A
    Walev, I
    Walker, B
    Weller, U
    Kehoe, M
    Palmer, M
    [J]. ARCHIVES OF MICROBIOLOGY, 1996, 165 (02) : 73 - 79
  • [4] ANTHRAX TOXIN - CHANNEL-FORMING ACTIVITY OF PROTECTIVE ANTIGEN IN PLANAR PHOSPHOLIPID-BILAYERS
    BLAUSTEIN, RO
    KOEHLER, TM
    COLLIER, RJ
    FINKELSTEIN, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) : 2209 - 2213
  • [5] DIFFUSION LIMITATION IN THE BLOCK BY SYMMETRICAL TETRAALKYLAMMONIUM IONS OF ANTHRAX TOXIN CHANNELS IN PLANAR PHOSPHOLIPID-BILAYER MEMBRANES
    BLAUSTEIN, RO
    FINKELSTEIN, A
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 1990, 96 (05) : 943 - 957
  • [6] THE CRYSTAL-STRUCTURE OF DIPHTHERIA-TOXIN
    CHOE, S
    BENNETT, MJ
    FUJII, G
    CURMI, PMG
    KANTARDJIEFF, KA
    COLLIER, RJ
    EISENBERG, D
    [J]. NATURE, 1992, 357 (6375) : 216 - 222
  • [7] STRUCTURE-FUNCTION OF THE CHANNEL-FORMING COLICINS
    CRAMER, WA
    HEYMANN, JB
    SCHENDEL, SL
    DERIY, BN
    COHEN, FS
    ELKINS, PA
    STAUFFACHER, CV
    [J]. ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1995, 24 : 611 - 641
  • [8] THE PHOTOSYNTHETIC REACTION CENTER FROM THE PURPLE BACTERIUM RHODOPSEUDOMONAS-VIRIDIS
    DEISENHOFER, J
    MICHEL, H
    [J]. SCIENCE, 1989, 245 (4925) : 1463 - 1473
  • [9] A mechanism for toxin insertion into membranes is suggested by the crystal structure of the channel-forming domain of colicin E1
    Elkins, P
    Bunker, A
    Cramer, WA
    Stauffacher, CV
    [J]. STRUCTURE, 1997, 5 (03) : 443 - 458
  • [10] BACILLUS-THURINGIENSIS CRYLA(A) INSECTICIDAL TOXIN - CRYSTAL-STRUCTURE AND CHANNEL FORMATION
    GROCHULSKI, P
    MASSON, L
    BORISOVA, S
    PUSZTAICAREY, M
    SCHWARTZ, JL
    BROUSSEAU, R
    CYGLER, M
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1995, 254 (03) : 447 - 464
1234567